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Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.
SUMMARIES FOR PATIENTS
The Efficacy of the Drug Epoprostenol in the Treatment of Pulmonary Hypertension Associated with Scleroderma
21 March 2000 | Volume 132 Issue 6 | Page 425
Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine.
The summary below is from the full report titled "Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease. A Randomized, Controlled Trial.". It is in the 21 March 2000 issue of Annals of Internal Medicine (volume 132, pages 425-433). The authors are D.B. Badesch, V.F. Tapson, M.D. McGoon, B.H. Brundage, L.J. Rubin, F.M. Wigley, S. Rich, R.J. Barst, P.S. Barrett, K.M. Kral, M.M. Jöbsis, J.E. Loyd, S. Murali, A. Frost, R. Girgis, R.C. Bourge, D.D. Ralph, C.G. Elliott, N.S. Hill, D. Langleben, R.J. Schilz, V.V. McLaughlin, I.M. Robbins, B.M. Groves, S. Shapiro, T.A. Medsger Jr., S.P. Gaine, E. Horn, J.C. Decker, and K. Knob.
What is the problem and what is known about it so far?
Pulmonary hypertension (high blood pressure in the arteries that go to the lungs) can produce disabling shortness of breath and often causes death. It can occur on its own (primary pulmonary hypertension) but is usually the result of an underlying lung disease, such as scleroderma (secondary pulmonary hypertension). No proven therapies for pulmonary hypertension are known, but epoprostenol, a drug that can dilate narrowed arteries, has shown promise in the treatment of patients with primary pulmonary hypertension.
Why did the researchers do this particular study?
The researchers wanted to see if epoprostenol would be useful in treating pulmonary hypertension that is secondary to scleroderma.
Who was studied?
One hundred eleven patients from 17 pulmonary hypertension centers in the United States with pulmonary hypertension associated with scleroderma.
How was the study done?
The researchers randomly assigned patients to receive either usual treatment or usual treatment plus epoprostenol. For 12 weeks, a pump delivered small amounts of epoprostenol continuously through a small tube inserted into a vein. The researchers measured the degree to which shortness of breath limited patients' activities by observing how far each patient could walk in 6 minutes, both at the beginning of the study and again after 1, 6, and 12 weeks of treatment.
hat did the researchers find?
The 56 patients who got epoprostenol increased the distance they could walk in 6 minutes from 270 to 316 meters. The 55 patients who received only usual therapy could walk 240 meters at the start of the study but only 192 meters at the end. Four epoprostenol patients and 5 usual therapy patients died during the course of the study. Frequent side effects of epoprostenol were jaw pain, diarrhea, nausea, and loss of appetite. Depression also occurred, but less commonly. In addition, patients who got epoprostenol had important side effects, including infection (4 patients) and bleeding (3 patients), that were related to the intravenous tube.
hat were the limitations of the study?
This study included too few patients to show whether epoprostenol improved survival among patients with scleroderma-associated pulmonary hypertension. Patients might find that the side effects and inconvenience of receiving epoprostenol continuously through an intravenous tube are not worth the improvement in exercise ability. It is also unclear whether the benefit observed in the 12 weeks of this study would continue over a longer period.
hat are the implications of the study?
Intravenous epoprostenol appears to improve exercise ability in patients with pulmonary hypertension due to scleroderma. However, associated side effects and the need for intravenous administration may limit the drug's usefulness.
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|
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|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J G Coghlan and C Handler Connective tissue associated pulmonary arterial hypertension Lupus, March 1, 2006; 15(3): 138 - 142. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 G. Engel and S. G Rockson Treprostinil for the treatment of severe digital necrosis in systemic sclerosis Vascular Medicine, February 1, 2005; 10(1): 29 - 32. [Abstract] [PDF]
|
|
|
|
 |
|
 Task Force members, N. Galie, A. Torbicki, R. Barst, P. Dartevelle, S. Haworth, T. Higenbottam, H. Olschewski, A. Peacock, G. Pietra, et al. Guidelines on diagnosis and treatment of pulmonary arterial hypertension: The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology Eur. Heart J., December 2, 2004; 25(24): 2243 - 2278. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Humbert, O. Sitbon, and G. Simonneau Treatment of Pulmonary Arterial Hypertension N. Engl. J. Med., September 30, 2004; 351(14): 1425 - 1436. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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