Figure 3. Summary relative risks for improvement or stabilization from baseline on the clinician-based impression of change scale, with caregiver input.

For donepezil versus placebo (Alzheimer disease [AD], all severity levels), the relative risk (RR) for improvement was statistically significant (P < 0.001) and tests for heterogeneity were not significant (I² = 0.0%; P = 0.762). For donepezil versus placebo (AD, all severity levels), the RR for improvement or stabilization was significant (P < 0.001). For donepezil versus placebo (mild to moderate vascular dementia), the RR for improvement or stabilization was not significant (P = 0.633) and tests for heterogeneity were not significant (I² = 55.1%; P = 0.136). For galantamine versus placebo (mild to moderate AD), the RR for improvement or stabilization was significant (P < 0.001) and tests for heterogeneity were not significant (I² = 19.9%; P > 0.20). For galantamine versus placebo (mild to moderate AD and vascular dementia), the RR for improvement or stabilization was significant (P = 0.002). For memantine versus placebo (AD, all severity levels), the RR for improvement was significant (P < 0.001) and tests for heterogeneity were not significant (I² = 0.0%; P > 0.20). For memantine versus placebo (AD, all severity levels), the RR for improvement or stabilization was significant (P < 0.001) and tests for heterogeneity were not significant (I² = 13.8%; P > 0.20). For rivastigmine versus placebo (AD, all severity levels), the RR for improvement or stabilization was not significant (P = 0.114).

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