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Weight-Based Low-Molecular-Weight Heparin versus Weight-Based Intravenous Unfractionated Heparin
Jodi B. Segal, MD, MPH;
Michael B. Streiff, MD; and
Eric B. Bass, MD, MPH
18 September 2007 | Volume 147 Issue 6 | Page 434
IN RESPONSE:
We appreciate the analyses by Dr. Umscheid and colleagues of a subgroup of the studies that were included in the systematic reviews we identified. These analyses confirm that there is little difference in outcomes (both efficacy and safety outcomes) between weight-based UFH and weight-based LMWH. We expect that practice patterns have changed since the publication of most of these trials; it is usual practice in most institutions to use a weight-based nomogram for intravenous heparin dosing. We are pleased that Dr. Umscheid and colleagues' analyses support the recommendations in the guidelines in this current era of weight-based dosing of both UFH and LMWH.
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From Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Potential Financial Conflicts of Interest: None disclosed.
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Vincenza Snow, Amir Qaseem, Patricia Barry, E. Rodney Hornbake, Jonathan E. Rodnick, Timothy Tobolic, Belinda Ireland, Jodi B. Segal, Eric B. Bass, Kevin B. Weiss, Lee Green, Douglas K. Owens, AND and the Joint American College of Physicians/American Academy of Family Physicians Panel on Deep Venous Thrombosis/Pulmonary Embolism*
- Annals 2007 146: 204-210.
[ABSTRACT][SUMMARY][Full Text]
