REPLY
Breast Cancer after Childhood Cancer
Lisa B. Kenney, MD, MPH
15 March 2005 | Volume 142 Issue 6 | Page 472
IN RESPONSE:
One of the objectives of our study was to investigate how hormonal and reproductive factors, known to modify breast cancer risk in the general population, modify secondary breast cancer risk in the unique population of childhood cancer survivors. We acknowledge that breast carcinogenesis is complex and that ovarian steroid hormones are not the only factors that contribute to an individual's breast cancer risk. However, in our attempt to identify risk factors for secondary breast cancer beyond radiation treatment, we chose to focus on hormonal and reproductive factors that are well established as breast cancer risk factors for the general population (1). In addition, our analysis was limited to data that were available on this cohort. Future studies on secondary breast cancer risk in childhood cancer survivors might address the potential risk factors that Dr. Rossi and Mr. Howard mention.
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From Dana-Farber Cancer Institute, Boston, MA 02115.
1. Gail MH, Brinton LA, Byar DP, Corle DK, Green SB, Schairer C, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst. 1989;81:1879-86. [PMID: 2593165].
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Articles
Breast Cancer after Childhood Cancer: A Report from the Childhood Cancer Survivor Study
Lisa B. Kenney, Yutaka Yasui, Peter D. Inskip, Sue Hammond, Joseph P. Neglia, Ann C. Mertens, Anna T. Meadows, Debra Friedman, Leslie L. Robison, AND Lisa Diller
- Annals 2004 141: 590-597.
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