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Aspirin Use and Risk for Colorectal Adenoma
Andrew T. Chan, MD, MPH, and
Charles S. Fuchs, MD, MPH
7 September 2004 | Volume 141 Issue 5 | Page 406
IN RESPONSE:
We appreciate Dr. Scovern's request for a clarification of our results. As we described in a footnote to our Table 4, we defined short-term use of aspirin as regular intake for no more than 5 consecutive years immediately preceding a participant's endoscopy. We did not directly examine nonconsecutive years of use or 5 years of aspirin use earlier in life. Thus, it remains unknown whether intermittent or remote aspirin use reduces risk for adenoma. However, on the basis of observed experience with nonsteroidal anti-inflammatory drugs in patients with familial polyposis (1), it appears that polyps will eventually recur after discontinuation of therapy.
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From Massachusetts General Hospital, Boston, MA 02114, and Dana-Farber Cancer Institute, Boston, MA 02115.
1. Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med. 1993;328:1313-6. [PMID: 8385741].[Abstract/Free Full Text]
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Articles
A Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma
Andrew T. Chan, Edward L. Giovannucci, Eva S. Schernhammer, Graham A. Colditz, David J. Hunter, Walter C. Willett, AND Charles S. Fuchs
- Annals 2004 140: 157-166.
[ABSTRACT][SUMMARY][Full Text]
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