Appendix Figure 2. Histograms of cost-effectiveness ratios resulting from probabilistic sensitivity analyses based on targeted (top) and universal (bottom) screening. A probabilistic sensitivity analysis was conducted in which 129 critical parameters were simultaneously varied over probability distributions on the basis of published 95% CIs or other reasonable ranges. A cost-effectiveness ratio was computed for each of 1000 iterations for both targeted and universal screening of people age 55 years. QALY = quality-adjusted life-year.

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