Appendix (Figure 6). Summary receiver-operating characteristic (ROC) curve for positron emission tomography with 18-fluorodeoxyglucose (FDG-PET). The ROC curves illustrate the tradeoff between sensitivity and specificity as the threshold that defines a positive test result varies from most stringent to least stringent. The ROC curve for FDG-PET is shown with 95% CIs (dotted lines). Black diamonds represent individual study estimates of sensitivity and specificity. Four studies reported perfect sensitivity and specificity (black square). The point on the summary ROC curve that corresponds to the median specificity reported in 13 studies of FDG-PET for pulmonary nodule diagnosis is shown (black circle). At this point, sensitivity and specificity were 94.2% and 83.3%, respectively.

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