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The Risk–Benefit Profile of Commonly Used Herbal Therapies
Edzard Ernst, MD, PhD, FRCP(Edin)
17 December 2002 | Volume 137 Issue 12 | Page 1008
IN RESPONSE:
I could not include the negative trial of St. John's wort by Shelton and colleagues (1) because it was published after I submitted my article to Annals. However, I do not agree that this trial, although rigorous, calls into question the results of previous meta-analyses. First, one trial cannot outweigh dozens of previously published studies. Second, and more important, Shelton and colleagues examined severe depression, while the vast majority of the previous investigations included only patients with mild to moderate depression. St. John's wort may well work for one type of depression but not for the other.
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Author and Article Information
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University of Exeter; Exeter EX2 4NT, United Kingdom
1. Shelton RC, Keller MB, Gelenberg A, Dunner DL, Hirschfeld R, Thase ME, et al. Effectiveness of St John's wort in major depression: a randomized controlled trial JAMA. 2001;285:1978-86. [PMID: 11308434].[Abstract/Free Full Text]
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Academia and Clinic
The Risk–Benefit Profile of Commonly Used Herbal Therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava
Edzard Ernst
- Annals 2002 136: 42-53.
[ABSTRACT][Full Text]
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