Figure 3. Results of treatment in patients with acquired aplastic anemia. A. Allogeneic bone marrow transplantation. Data are presented from individual hospital series in peer-reviewed publications from 1991 to 1997. The shaded area represents the 5-year probability of survival (with the same confidence intervals) of patients reported to the International Bone Marrow Transplant Registry (IBMTR) during this period. Adapted with permission from Horowitz (31); original source provides detailed information on each series. B. The continuing influence of age on survival, as reflected in IBMTR data. Adapted with permission from Horowitz (31). C. Comparative probability of survival after immunosuppression and bone marrow transplantation. The data are for patients reported to the Working Party on Severe Aplastic Anemia of The European Group for Blood and Marrow Transplantation in the 1980s and 1990s. Adapted with permission from Bacigalupo et al. (32); CSA = cyclosporine; FHCRC = Fred Hutchinson Cancer Research Center; MTX = methotrexate; UCLA = University of California, Los Angeles.

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