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REPLY
Testosterone and Resistance Training in AIDS
Steven K. Grinspoon, MD
3 July 2001 | Volume 135 Issue 1 | Page 65
IN RESPONSE:
We agree with Dr. Kamel that our data demonstrate a significant effect of supraphysiologic testosterone on muscle mass and strength in eugonadal men with AIDS wasting. The use of testosterone may therefore be considered to reverse sarcopenia in this population. However, we also agree that the long-term safety of supraphysiologic testosterone is unknown in this population. Although our data do not show adverse effects on prostate-specific antigen and hematocrit levels, the study was short and the longer-term safety effects remain unknown. Furthermore, our data do suggest a decrease in high-density lipoprotein cholesterol level, which may adversely affect such patients. In addition, long-term use of high-dose testosterone may result in suppression of gonadal function. In contrast, we have shown that progressive resistance training increases muscle mass and improves levels of high-density lipoprotein cholesterol. How these strategies will be best used in long-term clinical care remains to be determined.
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Harvard Medical School; Boston, MA 02108 (Grinspoon)
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Articles
Effects of Testosterone and Progressive Resistance Training in Eugonadal Men with AIDS Wasting: A Randomized, Controlled Trial
Steven Grinspoon, Colleen Corcoran, Kristin Parlman, Madeline Costello, Dan Rosenthal, Ellen Anderson, Takara Stanley, David Schoenfeld, Belton Burrows, Doug Hayden, Nesli Basgoz, AND Anne Klibanski
- Annals 2000 133: 348-355.
[ABSTRACT][SUMMARY][Full Text]
