LETTER
Warfarin: Less May Be Better
Michael D. Adelman, MD
15 August 1997 | Volume 127 Issue 4 | Page 332
TO THE EDITOR:
Harrison and colleagues [1] compared 10-mg and 5-mg loading doses of warfarin. Subsequent doses were determined by nomograms. Most physicians would consider the loading dose to be the dose or doses given over the first few days or until an end point had been reached (for example, an international normalized ratio [INR] of 2 to 3). It would be useful to know what the nomograms were to better evaluate the effect of the "loading dose" versus subsequent doses on the data.
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Author and Article Information
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Saint Vincent Health Center; Erie, PA 16502
Requests for Reprints: Michael A. LaCombe, MD, 103 South High Street, Bridgton, ME 04009.
1. Harrison L, Johnston M, Massicotte MP, Crowther M, Moffat K, Hirsh J. Comparison of 5-mg and 10-mg loading doses in initiation of warfarin therapy. Ann Intern Med. 1997; 126:133-6.
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