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15 August 1996 | Volume 125 Issue 4 | Pages 344-345
Gumber and Chopra [1] wrote an excellent review of extrahepatic manifestations of HCV infection. However, the review does not mention the association between HCV infection and B-cell non-Hodgkin lymphoma.
Ferri and colleagues [2] showed the presence of HCV infection in 17 patients (30%) of 50 unselected patients with B-cell non-Hodgkin lymphoma. Cryoglobulinemia was detected in 8% of these patients. This association is particularly significant compared with the prevalence of HCV infection in the healthy Italian population (1.3%). Pozzato and associates [3] showed a high prevalence of non-Hodgkin lymphoma in patients with cryoglobulinemia and HCV infection. The presence of viral genome in peripheral lymphocytes [4] suggests that the HCV genome is directly involved in the lymphoproliferative process that leads to lymphoma.
1. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1995; 123:615-20.
2. Ferri C, Caracciolo F, Zignegno AL, La Civita L, Monti M, Longombardo G, et al. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. Br J Haematol. 1994; 88:392-4.
3. Pozzato G, Mazzaro C, Crovatto M, Modolo ML, Ceselli S, Mazzi G, et al. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood. 1994; 84:3047-53.
4. Ferri C, Monti M, La Civita L, Longombardo G, Greco F, Pasero G, et al. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood. 1993; 82:3701-4. About Letters
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LETTER
Extrahepatic Manifestations of Hepatitis C Virus Infection
TO THE EDITOR:
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Hospital Rio Hortega, Valladolid, Spain
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This article has been cited by other articles:
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  J. D. Matthews and E. J. Bini Epidemiology, Diagnosis, and Treatment of Chronic Hepatitis C Journal of Pharmacy Practice, August 1, 2004; 17(4): 229 - 238. [Abstract] [PDF]
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