REPLY
Reevaluation of Amiodarone
Philip J. Podrid, MD
15 November 1995 | Volume 123 Issue 10 | Page 809
IN RESPONSE:
I appreciate the comments made by Drs. Ahmed and Goldman and by Dr. Ahmad. They correctly note other toxicities caused by amiodarone not specifically mentioned in my recent review. I recognize that many side effects were not mentioned, but my intent in the review was not to focus on the many toxicities caused by the drug. Its side-effect profile is well known and has been described in several extensive review articles [1-5]. Rather, my purpose was to critically examine the many reported clinical trials in which this agent has been used. Certainly, before any antiarrhythmic drug is administered, the risks of therapy must be weighed against the benefits. Indeed, the recommendations for amiodarone use were based on both these concerns.
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Author and Article Information
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Boston University Medical Center; Boston, MA 02118
1. Raeder EA, Podrid PJ, Lown B. Side effects and complications of amiodarone therapy. Am Heart J. 1985; 109:925-83.
2. Wilson JS, Podrid PJ. Side effects from amiodarone. Am Heart J. 1992; 121:158-71.
3. Harris L, McKenna WJ, Rowland E, Kickler DM. Side effects and possible contraindications of amiodarone use. Am Heart J. 1983; 106:916-21.
4. Naccarelli GV, Rinkenberger RC, Dougherty AH, Fitzgerald DM. Adverse effects of amiodarone. Med Toxicol Adverse Drug Exp. 1989; 4:246-53.
5. Mason JW. Amiodarone. N Engl J Med. 1987; 316:455-66.
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