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15 April 1995 | Volume 122 Issue 8 | Page 635
To investigate a potential genetic basis for Wegener granulomatosis, we screened 83 patients for human leukocyte antigen (HLA) A, B, and C, and DR-DQ markers and compared the frequencies of these phenotypes with those in 4039 normal persons screened for organ donation and 2163 normal persons randomly selected for histocompatibility testing. The results of chi-square analyses showed that B50 and DR9 phenotypes were statistically more likely to occur in patients with Wegener granulomatosis. In the two control groups, the frequency for the B50 phenotype was 1.5% and 2.2%, respectively, and the frequency for the DR9 phenotype was 1.7% and 1.6%, respectively (Table 1). The B50 and DR9 phenotypes, however, occurred in only 8.4% and 6.7% of patients, respectively. LETTER
HLA Typing in Patients with Wegener Granulomatosis
TO THE EDITOR:
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Other authors [1-4] have noted numerous different associations of particular HLA phenotypes in patients with Wegener granulomatosis. Our results, derived from a large series of patients, do not corroborate these findings. If a genetic predisposition exists for developing Wegener granulomatosis, it is not apparent from our analyses. However, other genetic markers may be important in the expression of this disease.
Author and Article Information
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 Top Author & Article Info References |
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References
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TopAuthor & Article InfoReferences |
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1. Strimlan CV, Taswell HF, Kueppen F, DeRemee RA, McDonald TJ. HLA antigens of patients with Wegener's granulomatosis. Tissue Antigens. 1978; 11:129-31.
2. Beigel A, Lehmann H, Westphal E. The spectrum of histocompatibility antigens (HLA) in Wegener's granulomatosis. Arch Otolaryngol. 1980; 233:157-60.
3. Elkon KB, Sutherland DC, Rees AJ, Hughes GR, Batchelor JR. HLA antigen frequencies in systemic vasculitis: increase in HLA-DR2 in Wegener's granulomatosis. Arthritis Rheum. 1983; 26:102-5.
4. Papiha SS, Murty GE, Ad'Hiah AH, Mains BT, Venning M. Association of Wegener's granulomatosis with HLA antigens and other geneticmarkers. Ann Rheum Dis. 1992; 51:246-8.
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