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LETTER

Aseptic Meningitis and Intravenous Immunoglobulin Therapy

Yadollah Harati and Aziz Taher Shaibani

15 February 1995 | Volume 122 Issue 4 | Pages 316-317

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TO THE EDITOR:

Sekul and colleagues [1] described the association between aseptic meningitis and high-dose intravenous immunoglobulin and reported that 11% (6 of 54) of their patients developed aseptic meningitis after receiving intravenous immunoglobulin. However, they did not mention the specific immunoglobulin product or products they used, although they asserted that a change in the "commercial lot or product, for unknown reasons, was effective in preventing the recurrence of aseptic meningitis".

Considering the high incidence of aseptic meningitis reported by these authors and the fact that different intravenous immunoglobulin products vary in the type and amount of the vehicle and in their immunoglobulin contents, it would be useful if the authors provided readers with the brand name of the product or products used in their patients.

REFERENCE

Top REFERENCE

1. Sekul EA, Cupler EJ, Dalakas MC. Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors. Ann Intern Med. 1994; 121:259-62.

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This article has been cited by other articles:

				M. C. Dalakas Mechanisms of action of IVIg and therapeutic considerations in the treatment of acute and chronic demyelinating neuropathies Neurology, December 24, 2002; 59(90126): S13 - 21. [Abstract] [Full Text]

				D. Karussis and O. Abramsky Is the Routine Use of Intravenous Immunoglobulin Treatment in Neurologic Disorders Justified?: No Arch Neurol, August 1, 1999; 56(8): 1028 - 1032. [Full Text] [PDF]

				G. Moris and J. C. Garcia-Monco The Challenge of Drug-Induced Aseptic Meningitis Arch Intern Med, June 14, 1999; 159(11): 1185 - 1194. [Abstract] [Full Text] [PDF]

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