REPLY
Does Race Predispose to Angiotensin-associated Angioneurotic Edema?
W. Dallas Hall and
Zafar H. Israili
15 December 1993 | Volume 119 Issue 12 | Page 1224
IN RESPONSE:
The observation of Drs. Brown and Nadeau is interesting. As they note, the data are insufficient to confirm the observed disparity in the incidence of ACE inhibitor-induced angioneurotic edema between blacks and whites. Angioneurotic edema was not one of the adverse effects reported in a study of 112 black patients with hypertension who were treated with captopril [1]. We agree with Drs. Brown and Nadeau that rigorous pharmacoepidemiologic studies are needed to confirm or refute their observation. It appears that women are at a greater risk for the development of angioneurotic edema from ACE inhibitors [2]. We suggest that all subsequent reports of angioneurotic edema associated with ACE inhibitors should include the race of the patients.
1. Saunders E, Weir MR, Kong BW, Hollifield J, Gray J, Vertes V, et al. A comparison of the efficacy and safety of a ß-blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacks. Arch Intern Med. 1990; 150:1707-13.
2. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. Ann Intern Med. 1992; 117:234-42.
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