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LETTER
Does Sucralfate Impede Levothyroxine Therapy?
Farida Khan;
Evelyne Jeanniton; and
Maria Renedo
15 February 1993 | Volume 118 Issue 4 | Page 317
TO THE EDITOR:
We respond to a letter on the interaction of sucralfate and levothyroxine [1].
We studied 10 stable hypothyroid patients on levothyroxine replacement for whom 1 g of sucralfate was prescribed with levothyroxine to be taken in the morning. The results of thyroxine (T4) and thyroid-stimulating hormone (TSH) assays done before and after 6 weeks of sucralfate administration are shown in Table 1 below.
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Table 1. Effect of Sucralfate on Thyroxine and Thyroid-stimulating Hormone Levels in 10 Patients Receiving Levothyroxine Therapy*
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We conclude that sucralfate administration did not significantly interfere with the in-vivo absorption of levothyroxine in stable hypothyroid patients.
1. Havrankova J, Lahaie R. Levothyroxine binding by sucralfate. Ann Intern Med. 1992; 117:445-6.
2. Renedo M, Jeanniton E, Khan F. Drug interaction of sucralfate and synthroid in medically hypothyroid patients. Program and Abstracts, 74th Endocrine Annual Meeting. June 1992, Abstract No. 313; 130.
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M. I. Surks and R. Sievert
Drugs and Thyroid Function
N. Engl. J. Med.,
December 21, 1995;
333(25):
1688 - 1694.
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