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PowerPoint slides are available for most Figures at Annals.org

Systematic Review: Comparative Effectiveness and Harms of Treatments for Clinically Localized Prostate Cancer


Figure 3
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  		Appendix Figure 1. Study flow diagram.{webonly}

AUA = American Urological Association; RCT = randomized, controlled trial; RP = radical prostatectomy.

 

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  		Table 1. Summary of Evidence on the Comparative Effectiveness and Harms of Therapies for Localized Prostate Cancer

 

Figure 1
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  		Figure 1. Overall survival at time points, by treatment, from nonrandomized studies.

The symbol size is proportional to the number of patients: <50, 50–150, 150–300, or >300. Brachy = brachytherapy; C-EBRT = conformal external-beam radiation therapy, EBRT = external-beam radiation therapy; RP = radical prostatectomy; WW = watchful waiting.

 

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  		Figure 2. Complications of brachytherapy, radical prostatectomy, external-beam radiation therapy, conformal external-beam radiation therapy, nerve-sparing radical prostatectomy, and watchful waiting from nonrandomized studies.

The symbol size is proportional to the number of patients: <50, 50–150, 150–300, or >300.

 

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  		Appendix Table 1. Description and Quality of the Included Randomized Trials{webonly}

 

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  		Table 2. All-Cause Mortality in Randomized, Controlled Trials

 

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  		Appendix Table 2. Biochemical/Clinical Progression or Recurrence in Randomized, Controlled Trials from the Era of Prostate-Specific Antigen Testing{webonly}

 

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  		Appendix Figure 2. Biochemical progression–free survival after cryotherapy or high-intensity focused ultrasonography among patients in nonrandomized clinical trials and case series.{webonly}

*Combined with transurethral resection of the prostate.

 

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  		Appendix Figure 3. Clinical outcomes after laparoscopic radical prostatectomy, robotic-assisted radical prostatectomy, or intensity-modulated radiation therapy.{webonly}

PSA = prostate-specific antigen.

 

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  		Appendix Table 3. Patient Characteristics and Response to Therapy at 24 Months of Follow-up in the Prostate Cancer Outcomes Study, by Treatment{webonly}

 



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