The Efficacy and Safety of Multivitamin and Mineral Supplement Use To Prevent Cancer and Chronic Disease in Adults: A Systematic Review for a National Institutes of Health State-of-the-Science Conference

Established in 1927 by the American College of Physicians

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The Efficacy and Safety of Multivitamin and Mineral Supplement Use To Prevent Cancer and Chronic Disease in Adults: A Systematic Review for a National Institutes of Health State-of-the-Science Conference

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Table 1. Characteristics of Randomized, Controlled Trials on the Efficacy of Multivitamin and Mineral Supplement Use in Primary Prevention of Chronic Disease*

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Table 2. Quality of Randomized, Controlled Trials on the Efficacy of Multivitamin and Mineral Supplements in Primary Prevention of Chronic Disease*

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Figure 1. Relative risk for cancer with use of multivitamin and mineral supplements.

The lines represent 95% CIs, the midpoints of the lines represent the relative risk estimates, and the size of the boxes represents the relative size of the study sample. SU.VI.MAX = SUpplémentation en VItamines et Minéraux AntioXydants. *Vitamin E + selenium + ß-carotene + zinc + vitamin C. ${dagger}$ Vitamin E + selenium + ß-carotene.

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Figure 2. Relative risk for all-cause mortality with use of multivitamin and mineral supplements.

The lines represent 95% CIs, the midpoints of the lines represent the relative risk estimates, and the size of the boxes represents the relative size of the study sample. AREDS = Age-Related Eye Disease Study; SU.VI.MAX = SUpplémentation en VItamines et Minéraux AntioXydants. *Vitamin E + selenium + ß-carotene + zinc + vitamin C. ${dagger}$ Vitamin E + selenium + ß-carotene. ${ddagger}$ Vitamin E + vitamin C + ß-carotene.

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Table 3. Grade of the Evidence on the Efficacy of Multivitamin and Mineral Supplements in Primary Prevention of Chronic Disease*