The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial

Established in 1927 by the American College of Physicians

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The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial

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Figure 1. Randomly assigned participants by treatment group and annual visit.

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Table 1. Prevalence of the Metabolic Syndrome and Its Components by Age and Sex in the Diabetes Prevention Program

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Table 2. Baseline Spearman Partial Correlations of Metabolic Syndrome Risk Factors and Homeostasis Model Assessment Score for Insulin Resistance Adjusted for Age, Sex, and Ethnicity

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Figure 2. Development of the metabolic syndrome by intervention group in the Diabetes Prevention Program.

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Table 3. Three-Year Incidence and Prevalence of Metabolic Syndrome Components among Diabetes Prevention Program Participants by Treatment Group

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Figure 3. Resolution of the metabolic syndrome by intervention group in the Diabetes Prevention Program.

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Appendix Figure. Venn diagram of the components of the metabolic syndrome. ${webonly}$ Numbers are numbers of participants at baseline. The shaded sections represent participants meeting the metabolic syndrome criteria as defined by the National Cholesterol Education Program Adult Panel II. BP = blood pressure; HDL-C = high-density lipoprotein cholesterol; TG = triglyceride.