Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart Failure

Established in 1927 by the American College of Physicians

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Systematic Review: Cardiac Resynchronization in Patients with Symptomatic Heart Failure

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Figure 1. Flow diagram of study selection. FDA = U.S. Food and Drug Administration.

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Table. Description of Randomized Trials Included in the Efficacy Review and Baseline Characteristics of Patients

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Appendix Table 1. MEDLINE Search: Cardiac Resynchronization for Heart Failure (Basic Search)

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Appendix Table 2. EMBASE Search: Cardiac Resynchronization for Heart Failure (Basic Search)

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Appendix Table 3. Search of International Pharmaceutical Abstracts: Cardiac Resynchronization for Heart Failure (Basic Search)

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Appendix Table 4. PubMed Search: Cardiac Resynchronization for Heart Failure (Basic Search)

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Appendix Table 5. Search of Web of Science: Cardiac Resynchronization for Heart Failure (Basic Search)

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Appendix Table 6. MEDLINE Search: Cardiac Resynchronization for Heart Failure (Safety Search)

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Appendix Table 7. EMBASE Search: Cardiac Resynchronization for Heart Failure (Safety Search)

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Appendix Table 8. PubMed Search: Cardiac Resynchronization for Heart Failure (Safety Search)

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Appendix Table 9. Search of Web of Science: Cardiac Resynchronization for Heart Failure (Safety Search)

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Appendix Table 10. MEDLINE Search: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 11. EMBASE Search: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 12. Search of Cochrane Controlled Trials Register: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 13. Search of DARE (Database of Abstracts of Reviews of Effectiveness): Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 14. Search of Cochrane Database of Systematic Reviews: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 15. PubMed Search: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 16. Search of Web of Science: Cardiac Resynchronization for Heart Failure (Efficacy Search)

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Appendix Table 17. Description of Studies Included in the Safety Review and Baseline Characteristics of Patients

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Figure 2. All-cause mortality with cardiac resynchronization therapy (CRT) versus controls. CHF = congestive heart failure; COMPANION = Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure; CONTAK CD = Guidant CONTAK CD CRT-D System Trial; MIRACLE = Multicenter InSync Randomized Clinical Evaluation; MIRACLE-ICD = Multicenter InSync Randomized Clinical Evaluation ICD [implantable cardioverter-defibrillator]; MUSTIC-AF = Multisite Stimulation in Cardiomyopathies Atrial Fibrillation; MUSTIC-SR = Multisite Stimulation in Cardiomyopathies Sinus Rhythm; PATH-CHF = Pacing Therapies for Congestive Heart Failure; RR = relative risk.

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Figure 3. Heart failure hospitalizations with cardiac resynchronization therapy (CRT) versus controls. CHF = congestive heart failure; CONTAK-CD = Guidant CONTAK CD CRT-D System Trial; MIRACLE = Multicenter InSync Randomized Clinical Evaluation; MIRACLE-ICD = Multicenter InSync Randomized Clinical Evaluation ICD [implantable cardioverter-defibrillator]; MUSTIC- AF = Multisite Stimulation in Cardiomyopathies Atrial Fibrillation; MUSTIC-SR = Multisite Stimulation in Cardiomyopathies Sinus Rhythm; RR = relative risk.

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Figure 4. Changes in quality of life with cardiac resynchronization therapy (CRT) versus controls (based on the Minnesota Living with Heart Failure [MLWHF] Questionnaire). CHF = congestive heart failure; COMPANION = Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure; CONTAK- CD = Guidant CONTAK CD CRT-D System Trial; MIRACLE = Multicenter InSync Randomized Clinical Evaluation; MIRACLE-ICD = Multicenter InSync Randomized Clinical Evaluation ICD [implantable cardioverter-defibrillator]; MUSTIC-AF = Multisite Stimulation in Cardiomyopathies Atrial Fibrillation; MUSTIC-SR = Multisite Stimulation in Cardiomyopathies Sinus Rhythm; PATH-CHF = Pacing Therapies for Congestive Heart Failure.