Implantable Cardioverter Defibrillators in Primary and Secondary Prevention

A Systematic Review of Randomized, Controlled Trials

View larger version (33K): [in a new window]   Figure 1. Selection of trials included in the meta-analysis. RCT = randomized, controlled trial.

View larger version (28K): [in a new window]   Figure 2. Sudden cardiac death for included trials. Relative risk (RR) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial.

View larger version (28K): [in a new window]   Figure 3. All-cause mortality for included trials. Relative risk (RR) is shown with box size proportional to sample size; lines indicate 95% CIs. For each stratum, the diamond represents the pooled analysis. AVID = Antiarrhythmic versus Implantable Defibrillator; CABG Patch = Coronary Artery Bypass Graft Patch Trial; CASH = Cardiac Arrest Study Hamburg; CAT = Cardiomyopathy Trial; CIDS = Canadian Implantable Defibrillator Study; ICD = implantable cardioverter defibrillator; MADIT = Multicenter Automatic Defibrillator Implantation Trial; MADIT II = Multicenter Automatic Defibrillator Implantation Trial II; MUSTT = Multicenter Unsustained Tachycardia Trial.