Cardioselective ß-Blockers in Patients with Reactive Airway Disease

A Meta-Analysis

View larger version (56K): [in a new window]   Figure 1. Effects of treatment on FEV1 for single-dose studies. Diamonds represent the extent of the confidence intervals. For group 1, test for heterogeneity, P > 0.2; test for overall effect, P < 0.001. For group 2, test for heterogeneity, P = 0.05; test for overall effect, P = 0.15. For both groups, test for heterogeneity, P = 0.09; test for overall effect, P < 0.001.

View larger version (48K): [in a new window]   Figure 2. Effects of treatment after use of ß2-agonists on FEV1 for single-dose studies. Diamonds represent the extent of the confidence intervals. For group 1, test for heterogeneity, P < 0.001; test for overall effect, P < 0.001. For group 2, test for heterogeneity, P > 0.2; test for overall effect, P = 0.2. For both groups, test for heterogeneity, P < 0.001; test for overall effect, P < 0.001.

View larger version (24K): [in a new window]   Figure 3. Effects of treatment on FEV1 for continued treatment studies. Diamonds represent the extent of the confidence intervals. For group 1, test for heterogeneity, P > 0.2; test for overall effect, P = 0.17. For group 2, test for overall effect, P > 0.2. For both groups, test for heterogeneity, P = 0.18; test for overall effect, P > 0.2.

View larger version (21K): [in a new window]   Figure 4. Effects of treatment after use of ß2-agonists on FEV1 for continued treatment studies. Diamonds represent the extent of the confidence intervals. For group 1, test for heterogeneity, P = 0.013; test for overall effect, P = 0.003. For group 2, test for overall effect, P > 0.2. For both groups, test for heterogeneity, P < 0.01; test for overall effect, P = 0.01.

View larger version (44K): [in a new window]   Appendix Figure. Results of search for and selection of trials.