Postmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease

View larger version (21K): [in a new window]   Figure 1. Relative risk or odds ratio for cardiovascular disease mortality. Error bars represent 95% CIs. HRT = hormone replacement therapy. "Current," "past," and "ever" use are categories used in the individual studies. "Any use" is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use).

View larger version (18K): [in a new window]   Figure 2. Relative risk or odds ratio for coronary artery disease mortality. Error bars represent 95% CIs. HRT = hormone replacement therapy. "Current," "past," and "ever" use are categories used in the individual studies. "Any use" is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use).

View larger version (16K): [in a new window]   Figure 3. Relative risk or odds ratio for cardiovascular disease incidence. Error bars represent 95% CIs. Reference 47 is pooled data from a previously published meta-analysis. HRT = hormone replacement therapy. "Current," "past," and "ever" use are categories used in the individual studies. "Any use" is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use).

View larger version (29K): [in a new window]   Figure 4. Relative risk or odds ratio for coronary artery disease incidence. Error bars represent 95% CIs. HRT = hormone replacement therapy; RCT = randomized, controlled trial; SES = socioeconomic status. "Current," "past," and "ever" use are categories used in the individual studies. "Any use" is a category created for this meta-analysis combining data from studies evaluating ever and never use of HRT with data from studies evaluating current, past, or never use (current + past + ever use). Adjustments for SES were adjustments as assessed by social class (12, 13), education (14, 15), and income.

View larger version (31K): [in a new window]   Appendix Figure. Search methods and results. HRT = hormone replacement therapy; RCT = randomized, controlled trial.