Chemoprevention of Breast Cancer: A Summary of the Evidence for the U.S. Preventive Services Task Force

Established in 1927 by the American College of Physicians

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Chemoprevention of Breast Cancer: A Summary of the Evidence for the U.S. Preventive Services Task Force

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Table 1. Summary of Four Randomized, Controlled Trials of Breast Cancer Chemoprevention

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Table 2. Comparison of Randomized, Controlled Trials of Breast Cancer Chemoprevention

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Table 3. Adverse Events in Four Randomized, Controlled Trials of Breast Cancer Chemoprevention

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Figure. Benefits and harms of chemoprevention with tamoxifen per 10 000 women in three age groups. Harms include endometrial cancer, stroke, and pulmonary embolism combined. Adapted from reference 49.

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Appendix (Figure 1). Analytical framework. KQ = key question. KQ 1: Do chemopreventive agents reduce mortality from breast cancer? KQ 2: Do chemopreventive agents reduce the incidence of breast cancer? KQ 3: Do chemopreventive agents have other beneficial effects? KQ 4: Do chemopreventive agents increase the risk for adverse effects? KQ 5: What are the costs associated with chemoprevention of breast cancer?

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Appendix (Figure 2). Article selection. RCTs = randomized, controlled trials.

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Appendix Table 1. Breast Cancer Chemoprevention: Inclusion and Exclusion Criteria

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Appendix Table 2. Search Strategy Results for Breast Cancer Chemoprevention

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Appendix Table 3. Review Criteria for Abstracts and Articles in Breast Cancer Chemoprevention

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Appendix Table 4. Summary Results from Literature Searches and Reviews