Postmenopausal Estrogen Replacement and Risk for Venous Thromboembolism

A Systematic Review and Meta-Analysis for the U.S. Preventive Services Task Force

View larger version (14K): [in a new window]   Figure 1. Risk for venous thromboembolism by year of estrogen use. Odds ratios for thromboembolic events were higher in the first or second year than in subsequent years in all six studies reporting results by year of use.

View larger version (21K): [in a new window]   Figure 2. Meta-analysis of estrogen studies. The pooled estimate of venous thromboembolism risk for all 12 studies meeting eligibility criteria was 2.14 (95% credible interval, 1.64 to 2.81). Numbers above the lines ending in arrows indicate the outer limits of the confidence intervals. PEPI = Postmenopausal Estrogen/Progestin Interventions trial.

View larger version (23K): [in a new window]   Appendix Figure. Flowchart diagram of search and selection of articles.