A Systematic Review of Newer Pharmacotherapies for Depression in Adults: Evidence Report Summary: Clinical Guideline, Part 2

View larger version (20K): [in a new window]   Figure 1. Meta-analysis of placebo compared with newer antidepressants for major depression in adults.N indicates number of participants; n indicates number of studies. GABA = -aminobutyric acid; HT = hydroxy-tryptophan; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor.

View larger version (20K): [in a new window]   Figure 2. Meta-analysis of older antidepressants compared with newer antidepressants for major depression in adults. N indicates number of participants; n indicates number of studies. HT = hydroxy-tryptophan; MAOI = monoamine oxidase inhibitor; NRI = norepinephrine reuptake inhibitor; RIMA = reversible inhibitor of monoamine oxidase A; SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin and noradrenaline reuptake inhibitor; TCA1 = first-generation tricyclic antidepressant; TCA2 = second-generation tricyclic antidepressant.

View larger version (19K): [in a new window]   Figure 3. Meta-analysis of newer antidepressants for dysthymia in adults.N indicates number of participants. *Response rates not given. HT = hydroxy-tryptophan; SSRI = selective serotonin reuptake inhibitor.

View larger version (21K): [in a new window]   Figure 4. Meta-analysis of hypericum (St. John's wort) for depressive disorders in adults.N indicates number of participants. The diamonds represent a summary estimate, derived from the individual studies listed above the diamonds. The center of each diamond is the point estimate, and the tails represent the 95% CIs.