Systematic Review: T-Cell-Based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update

Established in 1927 by the American College of Physicians

Abstract/Editors' Note | Full Text | PDF

FIGURES/TABLES SUMMARY PAGE

PowerPoint slides are available for most Figures at Annals.org

Systematic Review: T-Cell–Based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update

View this table:
[in this window]
[in a new window]

Appendix Table 1. Sensitivity of QuantiFERON-TB Gold (QFT) among Patients with Active Tuberculosis (TB) ${webonly}$

View this table:
[in this window]
[in a new window]

Appendix Table 2. Sensitivity of T-SPOT.TB among Patients with Active Tuberculosis (TB) ${webonly}$

View this table:
[in this window]
[in a new window]

Appendix Table 3. Specificity of QuantiFERON-TB Gold (QFT) in Bacille Calmette-Guérin (BCG)–Vaccinated and Non–BCG-Vaccinated Patients with an Expected Low Prevalence of Tuberculous Infection ${webonly}$

View this table:
[in this window]
[in a new window]

Appendix Table 4. Specificity of Enzyme-Linked Immunospot (ELISpot) and T-SPOT.TB in Bacille Calmette-Guérin (BCG)–Vaccinated and Nonvaccinated Participants with Expected Low Prevalence of Tuberculous Infection ${webonly}$

View larger version (45K):
[in this window]
[in a new window]

Figure 1. Forest plot of studies estimating sensitivity of interferon- ${gamma}$ release assays in patients with active tuberculosis as a surrogate for latent tuberculous infection.

Point estimates for sensitivity and 95% CIs are shown along with pooled estimates. Top. QuantiFERON-TB Gold (16 studies). Middle. QuantiFERON-TB Gold In-Tube (6 studies). Bottom. T-SPOT.TB (13 studies).

View this table:
[in this window]
[in a new window]

Appendix Table 5. Head-to-Head Comparisons of Sensitivity of QuantiFERON-TB (QFT) Gold versus T-SPOT.TB among Patients with Active Tuberculosis ${webonly}$

View larger version (47K):
[in this window]
[in a new window]

Figure 2. Forest plot of studies estimating specificity of interferon- ${gamma}$ release assays in populations at very low risk for latent tuberculous infection.

Point estimates for specificity and 95% CIs are shown along with pooled estimates. Top. QuantiFERON-TB Gold and QuantiFERON-TB Gold In-Tube (BCG non-vaccinated; 8 studies). Middle. QuantiFERON-TB Gold and QuantiFERON-TB Gold In-Tube (BCG vaccinated; 8 studies). Bottom. T-SPOT.TB (predominantly BCG vaccinated; 6 studies).

View larger version (45K):
[in this window]
[in a new window]

Figure 3. Forest plot of studies estimating sensitivity and specificity of the tuberculin skin test.

Point estimates for sensitivity and specificity and 95% CIs are shown along with pooled estimates. Top. Sensitivity (20 studies). Middle. Specificity in non–bacille Calmette–Guérin-vaccinated populations (6 studies). Bottom. Specificity in bacille Calmette–Guérin-vaccinated populations (6 studies).