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Systematic Review: The Effects of Growth Hormone on Athletic Performance


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Appendix Table 1. Search Strategy

 

Figure 1
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Figure. Trial flow.

*Sum may be greater than total number excluded because some studies had multiple reasons for exclusion. GH = growth hormone.

 

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Table 1. Baseline Characteristics of Participants and Study Intervention

 

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Table 2. Study Quality

 

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Appendix Table 2. Key Outcomes Available for Analysis

 

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Table 3. Summary Effect Sizes for Body Composition, Strength, and Basal Metabolism

 

Figure 1
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Appendix Figure 1. Effect of growth hormone (GH) on body composition.

We used a random-effects model and a weighted mean difference effect size to compare growth hormone–treated and non–growth hormone–treated participants. The black diamond represents the summary effect size for the outcome of interest. Values greater than 0 indicate that results under growth hormone treatment were higher than those without growth hormone treatment. The studies are ordered by mean effect size. *Male; {dagger}Female; {ddagger}High-dose group; §Low-dose group.

 

Figure 2
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Appendix Figure 2. Effect of growth hormone (GH) on strength.

We used a random-effects model and a weighted mean difference effect size to compare growth hormone–treated and non–growth hormone–treated participants. The black diamond represents the summary effect size for the outcome of interest. Values greater than 0 indicate that results under growth hormone treatment were higher than those without growth hormone treatment. The studies are ordered by mean effect size. 1RM = 1 repetition maximum.

 

Figure 3
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Appendix Figure 3. Effect of growth hormone (GH) on basal metabolism.

We used a random-effects model and a weighted mean difference effect size to compare growth hormone–treated and non–growth hormone–treated participants. The black diamond represents the summary effect size for the outcome of interest. Values greater than 0 indicate that results under growth hormone treatment were higher than those without growth hormone treatment. The studies are ordered by mean effect size. RER = respiratory exchange rate; RQ = respiratory quotient. *Low-dose group; data obtained from reference 50; {dagger}Low-dose growth hormone; {ddagger}High-dose growth hormone; data obtained from reference 50; §High-dose growth hormone.

 

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Table 4. Summary Effect for Exercise Capacity

 

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Table 5. Key Adverse Events

 





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