 |
 |
|
|
|  PubMed
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
4 May 2004 | Volume 140 Issue 9 | Pages 729-737
Myocardial infarction is the leading cause of congestive heart failure and death in the industrialized world. Current therapy is limited in preventing the progression of ventricular remodeling and congestive heart failure. Recent interest has focused on stem cells, which are undifferentiated and pluripotent cells that can proliferate, potentially self-renew, and differentiate into cardiomyocytes. Myocardial regeneration with stem-cell transplantation is a possible treatment option to reverse the deleterious hemodynamic and neurohormonal effects that occur after myocardial infarction and can lead to congestive heart failure. Various preclinical animal studies show the potential to regenerate myocardium and improve perfusion to the infarct area to improve cardiac function but also suggest that stem cells may have proarrhythmic effects. Early phase I clinical studies indicate that stem-cell transplantation is feasible and may have beneficial effects on ventricular remodeling after myocardial infarction. Future randomized clinical trials will establish the magnitude of the benefit and the effects on arrhythmias after stem-cell therapy.
Author and Article Information
From St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, New York, New York, and Cedars-Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Raj R. Makkar, MD, Division of Cardiology, Cardiac Catheterization Laboratory, Cedars-Sinai Medical Center, 8631 West 3rd Street #415E, Los Angeles, CA 90048; e-mail, raj.makkar{at}cshs.org.
Current Author Addresses: Dr. Lee: Division of Cardiology, St. Luke's-Roosevelt Hospital, 1111 Amsterdam Avenue, New York, NY 10025.
Dr. Makkar: Division of Cardiology, Cardiac Catheterization Laboratory, Cedars-Sinai Medical Center, 8631 West 3rd Street #415E, Los Angeles, CA 90048. REVIEW
Stem-Cell Transplantation in Myocardial Infarction: A Status Report
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  E. Lipsic, B. D. Westenbrink, P. van der Meer, P. van der Harst, A. A. Voors, D. J. van Veldhuisen, R. G. Schoemaker, and W. H. van Gilst Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit Eur J Heart Fail, January 1, 2008; 10(1): 22 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Gallegos and R. M. Bolman III Stem Cell Induced Regeneration of Myocardium Card. Surg. Adult, January 1, 2008; 3(2008): 1657 - 1668. [Full Text]
|
|
|
|
 |
|
 H. Sakamoto, L. M. Parish, H. Hamamoto, L. P. Ryan, T. J. Eperjesi, T. J. Plappert, B. M. Jackson, M. G. St John-Sutton, J. H. Gorman III, and R. C. Gorman Effect of Reperfusion on Left Ventricular Regional Remodeling Strains After Myocardial Infarction Ann. Thorac. Surg., November 1, 2007; 84(5): 1528 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Wu, Y. L. Liu, B. Zhou, and Z. C. Han Cellular therapy and myocardial tissue engineering: the role of adult stem and progenitor cells Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 770 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fernandes, J.-C. Amirault, G. Lande, J.-M. Nguyen, V. Forest, O. Bignolais, G. Lamirault, D. Heudes, J.-L. Orsonneau, M.-F. Heymann, et al. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias Cardiovasc Res, February 1, 2006; 69(2): 348 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. O'Neill IV, B. R. Wamhoff, G. K. Owens, and T. C. Skalak Mobilization of Bone Marrow-Derived Cells Enhances the Angiogenic Response to Hypoxia Without Transdifferentiation Into Endothelial Cells Circ. Res., November 11, 2005; 97(10): 1027 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sartore, M. Lenzi, A. Angelini, A. Chiavegato, L. Gasparotto, P. D. Coppi, R. Bianco, and G. Gerosa Amniotic mesenchymal cells autotransplanted in a porcine model of cardiac ischemia do not differentiate to cardiogenic phenotypes Eur. J. Cardiothorac. Surg., November 1, 2005; 28(5): 677 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. W. Gowdak, I. T. Schettert, C. E. Rochitte, L. A. F. Lisboa, L. A. O. Dallan, L. A. M. Cesar, J. E. Krieger, J. A. F. Ramires, and S. A. de Oliveira Cell Therapy Plus Transmyocardial Laser Revascularization for Refractory Angina Ann. Thorac. Surg., August 1, 2005; 80(2): 712 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Dudley Jr Beware of Cells Bearing Gifts: Cell Replacement Therapy and Arrhythmic Risk Circ. Res., July 22, 2005; 97(2): 99 - 101. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mancini and D. Burkhoff Mechanical Device-Based Methods of Managing and Treating Heart Failure Circulation, July 19, 2005; 112(3): 438 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Futterman and L. Lemberg Cardiac Repair With Autologous Bone Marrow Stem Cells Am. J. Crit. Care., November 1, 2004; 13(6): 512 - 518. [Full Text] [PDF]
|
|
|
|
|
|
J. Appoo, C. Norris, S. Merali, M. M. Graham, A. Koshal, M. L. Knudtson, and W. A. Ghali Long-Term Outcome of Isolated Coronary Artery Bypass Surgery in Patients With Severe Left Ventricular Dysfunction Circulation, September 14, 2004; 110(11_suppl_1): II-13 - II-17. [Abstract] [Full Text] [PDF]
|
|
