 |
 |
|
|
|  PubMed
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2 March 2004 | Volume 140 Issue 5 | Pages 321-329
Background: Despite the widespread household use of cleaning and personal hygiene products containing antibacterial ingredients, their effects on the incidence of infectious disease symptoms have not been studied.
Objective: To evaluate the effect of antibacterial cleaning and handwashing products for consumers on the occurrence of infectious disease symptoms in households.
Design: Randomized, double-blind clinical trial.
Setting: Northern Manhattan inner-city neighborhood, New York.
Participants: 238 primarily Hispanic households (1178 persons) that included at least one preschool-age child.
Interventions: Households were randomly assigned to use either antibacterial or nonantibacterial products for general cleaning, laundry, and handwashing. All products were commercially available, but the packaging was blinded and the products were provided free to participants.
Measurements: Hygiene practices and infectious disease symptoms were monitored by weekly telephone calls, monthly home visits, and quarterly interviews for 48 weeks.
Results: Symptoms were primarily respiratory: During 26.2% (717 of 2736) of household-months, 23.3% (640 of 2737) of household-months, and 10.2% (278 of 2737) of household-months, one or more members of the household had a runny nose, cough, or sore throat, respectively. Fever was present during 11% (301 of 2737) of household-months, vomiting was present in 2.2% (61 of 2737), diarrhea was present in 2.5% (69 of 2737), and boils or conjunctivitis were present in 0.77% (21 of 2737). Differences between intervention and control groups were not significant for any symptoms (all unadjusted and adjusted relative risks included 1.0) or for numbers of symptoms (overall incidence density ratio, 0.96 [95% CI, 0.82 to 1.12]).
Conclusions: The tested antibacterial products did not reduce the risk for symptoms of viral infectious diseases in households that included essentially healthy persons. This does not preclude the potential contribution of these products to reducing symptoms of bacterial diseases in the home.
Editors' Notes
Context
Contribution
Implications
–The Editors
Author and Article Information
From Columbia University and Columbia University Medical Center, New York, New York.
Acknowledgments: The authors thank Ms. Delmy Miranda and Dr. Angela Lopez, who served as interviewers in the research team.
Grant Support: By the National Institute for Nursing Research, National Institutes of Health (grant 1 RO1 NR05251). Procter & Gamble, Cincinnati, Ohio, provided products packaged in a blinded fashion.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Elaine Larson, PhD, Columbia University School of Nursing, 630 West 168th Street, New York, NY 10032; e-mail, ELL23{at}Columbia.edu.
Current Author Addresses: Drs. Larson and Lin: Columbia University School of Nursing, 630 West 168th Street, New York, NY 10032.
Dr. Gomez-Pichardo: Center for Liver Disease and Transplantation, 622 West 168 Street PH14, P&S 9-501, New York, NY 10032.
Dr. Della-Latta: Clinical Microbiology Laboratory, Children's Hospital of New York, 3S Room 325, 622 West 168th Street, New York, NY 10032.
Author Contributions: Conception and design: E.L. Larson.
Analysis and interpretation of the data: E.L. Larson, S.X. Lin.
Drafting of the article: E.L. Larson, S.X. Lin, P. Della-Latta.
Critical revision of the article for important intellectual content: E.L. Larson, S.X. Lin, P. Della-Latta.
Final approval of the article: E.L. Larson, S.X. Lin, C. Gomez-Pichardo, P. Della-Latta.
Provision of study materials or patients: P. Della-Latta.
Statistical expertise: S.X. Lin.
Obtaining of funding: E.L. Larson.
Administrative, technical, or logistic support: P. Della-Latta.
Collection and assembly of data: E.L. Larson, S.X. Lin, C. Gomez-Pichardo. ARTICLE
Effect of Antibacterial Home Cleaning and Handwashing Products on Infectious Disease Symptoms
A Randomized, Double-Blind Trial
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  R. T. Carson, E. Larson, S. B. Levy, B. M. Marshall, and A. E. Aiello Use of antibacterial consumer products containing quaternary ammonium compounds and drug resistance in the community J. Antimicrob. Chemother., November 1, 2008; 62(5): 1160 - 1162. [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Aiello, R. M. Coulborn, V. Perez, and E. L. Larson Effect of Hand Hygiene on Infectious Disease Risk in the Community Setting: A Meta-Analysis Am J Public Health, August 1, 2008; 98(8): 1372 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Fuls, N. D. Rodgers, G. E. Fischler, J. M. Howard, M. Patel, P. L. Weidner, and M. H. Duran Alternative Hand Contamination Technique To Compare the Activities of Antimicrobial and Nonantimicrobial Soaps under Different Test Conditions Appl. Envir. Microbiol., June 15, 2008; 74(12): 3739 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Nicolle Hygiene: What and why? Can. Med. Assoc. J., March 13, 2007; 176(6): 767 - 768. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pancholi, M. Healy, T. Bittner, R. Webb, F. Wu, A. Aiello, E. Larson, and P. D. Latta Molecular Characterization of Hand Flora and Environmental Isolates in a Community Setting J. Clin. Microbiol., October 1, 2005; 43(10): 5202 - 5207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Sandora, E. M. Taveras, M.-C. Shih, E. A. Resnick, G. M. Lee, D. Ross-Degnan, and D. A. Goldmann A Randomized, Controlled Trial of a Multifaceted Intervention Including Alcohol-Based Hand Sanitizer and Hand-Hygiene Education to Reduce Illness Transmission in the Home Pediatrics, September 1, 2005; 116(3): 587 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Lee, J. A. Salomon, J. F. Friedman, P. L. Hibberd, D. Ross-Degnan, E. Zasloff, S. Bediako, and D. A. Goldmann Illness Transmission in the Home: A Possible Role for Alcohol-Based Hand Gels Pediatrics, April 1, 2005; 115(4): 852 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Musher and B. L. Musher Contagious Acute Gastrointestinal Infections N. Engl. J. Med., December 2, 2004; 351(23): 2417 - 2427. [Full Text] [PDF]
|
|
|
|
 |
|
 Antibacterial household products don't reduce symptoms of infectious disease BMJ, August 21, 2004; 329(7463): . [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kemp Effect of antibacterial products AAP News, August 1, 2004; 25(2): 54 - 54. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lehman Evidently... Evid. Based Med., July 1, 2004; 9(4): 104 - 105. [Full Text] [PDF]
|
|
|
|
|
|
Other articles noted Evid. Based Med., July 1, 2004; 9(4): 127 - 128. [Full Text] [PDF]
|
|
|
|
 |
|
 Other articles noted: 06 Feb 2004 to 16 Apr 2004 Evid. Based Nurs., July 1, 2004; 7(3): e3 - e3. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Buekens, G. Keusch, J. Belizan, and Z. A. Bhutta Evidence-Based Global Health JAMA, June 2, 2004; 291(21): 2639 - 2641. [Full Text] [PDF]
|
|
|
|
 |
|
 Antibacterial Cleaning Products Don't Prevent Infectious Disease Symptoms Journal Watch Dermatology, April 28, 2004; 2004(428): 10 - 10. [Full Text]
|
|
|
|
 |
|
 Antibacterial Home Products Don't Halt Viruses Journal Watch Pediatrics and Adolescent Medicine, March 29, 2004; 2004(329): 2 - 2. [Full Text]
|
|
|
|
 |
|
 Antibacterial Cleaning Products Don't Prevent Infectious Disease Symptoms Journal Watch (General), March 19, 2004; 2004(319): 1 - 1. [Full Text]
|
|
|
|
 |
|
 J. T. Weber and J. M. Hughes Beyond Semmelweis: Moving Infection Control into the Community Ann Intern Med, March 2, 2004; 140(5): 397 - 398. [Full Text] [PDF]
|
|
