 |
 |
|
1 June 2004 | Volume 140 Issue 11 | Pages 951-957
More than 18 million Americans currently have diabetes mellitus. The economic and human cost of the disease is devastating. In the United States, diabetes is the most common cause of blindness among working-age adults, the most common cause of nontraumatic amputations and end-stage renal disease, and the sixth most common cause of death. For the cohort of Americans born in 2000, the estimated lifetime risk for diabetes is more than 1 in 3. In the next 50 years, the number of diagnosed cases of diabetes is predicted to increase by 165% in the United States, with the largest relative increases seen among African Americans, American Indians, Alaska Natives, Asian and Pacific Islanders, and Hispanic/Latino persons. Compelling scientific evidence indicates that lifestyle change prevents or delays the occurrence of type 2 diabetes in high-risk groups. This body of evidence from randomized, controlled trials conducted in 3 countries has definitively established that maintenance of modest weight loss through diet and physical activity reduces the incidence of type 2 diabetes in high-risk persons by about 40% to 60% over 3 to 4 years. The number of persons at high risk for type 2 diabetes is similar to the number of persons who have diabetes. This paper summarizes scientific evidence supporting lifestyle intervention to prevent type 2 diabetes and discusses major policy challenges to broad implementation of lifestyle intervention in the health system.
*For a list of the members of the Centers for Disease Control and Prevention Primary Prevention Working Group, see the Appendix.
Author and Article Information
From the Centers for Disease Control and Prevention, Atlanta, Georgia.
Disclaimer: The writing group (David F. Williamson, PhD, MS; Frank Vinicor, MD, MPH; and Barbara A. Bowman, PhD) of the Centers for Disease Control and Prevention Primary Prevention Working Group takes responsibility for the content of this article.
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Barbara A. Bowman, PhD, Division of Diabetes Translation, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS K10, Atlanta, GA 30341. SUPPLEMENT: DIABETES TRANSLATION AND PUBLIC HEALTH: 25 YEARS OF CDC RESEARCH AND PROGRAMS
K.M. Venkat Narayan, MD, MPH, MBA; Leonard Jack Jr., PhD; and Christine Laine, MD, MPH, Editors
Primary Prevention of Type 2 Diabetes Mellitus by Lifestyle Intervention: Implications for Health Policy
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  E. B. Larson Physical Activity for Older Adults at Risk for Alzheimer Disease JAMA, September 3, 2008; 300(9): 1077 - 1079. [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Morrato, J. O. Hill, H. R. Wyatt, V. Ghushchyan, and P. W. Sullivan Physical Activity in U.S. Adults With Diabetes and At Risk for Developing Diabetes, 2003 Diabetes Care, February 1, 2007; 30(2): 203 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sriskantharajah and J. Kai Promoting physical activity among South Asian women with coronary heart disease and diabetes: what might help? Fam. Pract., February 1, 2007; 24(1): 71 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E.R. Warburton, C. W. Nicol, and S. S.D. Bredin Health benefits of physical activity: the evidence. Can. Med. Assoc. J., March 14, 2006; 174(6): 801 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Morrato, J. O. Hill, H. R. Wyatt, V. Ghushchyan, and P. W. Sullivan Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more? Diabetes Care, March 1, 2006; 29(3): 543 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lupi, S. D. Guerra, M. Bugliani, U. Boggi, F. Mosca, S. Torri, S. D. Prato, and P. Marchetti The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets Eur. J. Endocrinol., February 1, 2006; 154(2): 355 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. G. Katakam, J. A. Snipes, C. D. Tulbert, K. Mayanagi, A. W. Miller, and D. W. Busija Impaired endothelin-induced vasoconstriction in coronary arteries of Zucker obese rats is associated with uncoupling of [Ca2+]i signaling Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R145 - R153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Bazzano, M. Serdula, and S. Liu Prevention of Type 2 Diabetes by Diet and Lifestyle Modification J. Am. Coll. Nutr., October 1, 2005; 24(5): 310 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Khan, S. Riazi, X. Hu, J. Song, J. B. Wade, and C. A. Ecelbarger Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone Am J Physiol Renal Physiol, August 1, 2005; 289(2): F442 - F450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Sullivan, E. H. Morrato, V. Ghushchyan, H. R. Wyatt, and J. O. Hill Obesity, Inactivity, and the Prevalence of Diabetes and Diabetes-Related Cardiovascular Comorbidities in the U.S., 2000-2002 Diabetes Care, July 1, 2005; 28(7): 1599 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lada and U. Idrees Toxicity of Oral Agents Used to Treat Diabetes Journal of Pharmacy Practice, June 1, 2005; 18(3): 145 - 156. [Abstract] [PDF]
|
|
|
|
 |
|
 P. R. Moreno and V. Fuster New aspects in the pathogenesis of diabetic atherothrombosis J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2293 - 2300. [Abstract] [Full Text] [PDF]
|
|
Article
