Article    Table of Contents                    Full Text of this article    PDF of this article (PDFs free after 6 months)    Figures/Tables List  Services    Send comment/rapid response letter    Notify a friend about this article    Alert me when this article is cited    Add to Personal Archive    Download to Citation Manager    ACP Search                            Get Permissions  Google Scholar    Search for Related Content  PubMed Articles in PubMed by Author:    Hurst, R. T.    Lee, R. W.    Related Articles in PubMed    PubMed Citation    PubMed

REVIEW

Increased Incidence of Coronary Atherosclerosis in Type 2 Diabetes Mellitus: Mechanisms and Management

R. Todd Hurst, MD, and Richard W. Lee, MD

18 November 2003 | Volume 139 Issue 10 | Pages 824-834

Type 2 diabetes mellitus is a metabolic disease of carbohydrate metabolism. However, it should also be considered a vascular disease because diabetic patients have a strong predilection for atherosclerosis. With the increasing prevalence and earlier age at onset of diabetes, the projected effect of diabetes on cardiovascular health and resource utilization is sobering. The mechanisms of the high rate of atherosclerosis are multifactorial and give clinicians and researchers insights into potential preventive therapies. Effective pharmacologic and lifestyle interventions are available for primary and secondary prevention of cardiovascular complications. However, data show that these interventions continue to be underutilized. Treatment of patients with type 2 diabetes and coronary artery disease is similar to that of patients with coronary artery disease alone. However, patients with diabetes benefit more from treatments that reduce coronary artery disease risk.

Author and Article Information

From Mayo Clinic, Scottsdale, Arizona.

Potential Financial Conflicts of Interest: None disclosed.

Requests for Single Reprints: Richard W. Lee, MD, Division of Cardiovascular Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259.

Current Author Addresses: Drs. Hurst and Lee: Division of Cardiovascular Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ85259.

This article has been cited by other articles:

				M. J. Abrahamson A 74-Year-Old Woman With Diabetes JAMA, January 10, 2007; 297(2): 196 - 204. [Abstract] [Full Text] [PDF]

				C. Nielson, T. Lange, and N. Hadjokas Blood Glucose and Coronary Artery Disease in Nondiabetic Patients Diabetes Care, May 1, 2006; 29(5): 998 - 1001. [Abstract] [Full Text] [PDF]

				D. G. Johns, Z. Ao, M. Eybye, A. Olzinski, M. Costell, S. Gruver, S. A. Smith, S. A. Douglas, and C. H. Macphee Rosiglitazone Protects against Ischemia/Reperfusion-Induced Leukocyte Adhesion in the Zucker Diabetic Fatty Rat J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1020 - 1027. [Abstract] [Full Text] [PDF]

				A. Dibra, A. Kastrati, J. Mehilli, J. Pache, H. Schuhlen, N. von Beckerath, K. Ulm, R. Wessely, J. Dirschinger, A. Schomig, et al. Paclitaxel-Eluting or Sirolimus-Eluting Stents to Prevent Restenosis in Diabetic Patients N. Engl. J. Med., August 18, 2005; 353(7): 663 - 670. [Abstract] [Full Text] [PDF]

				S. E. Inzucchi, F. A. Masoudi, Y. Wang, M. Kosiborod, J. M. Foody, J. F. Setaro, E. P. Havranek, and H. M. Krumholz Insulin-Sensitizing Antihyperglycemic Drugs and Mortality After Acute Myocardial Infarction: Insights from the National Heart Care Project Diabetes Care, July 1, 2005; 28(7): 1680 - 1689. [Abstract] [Full Text] [PDF]

				L. R. LOPEZ, B. L. HURLEY, D. F. SIMPSON, and E. MATSUURA Oxidized Low-Density Lipoprotein/{beta}2-Glycoprotein I Complexes and Autoantibodies in Patients with Type 2 Diabetes Mellitus Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 97 - 103. [Abstract] [Full Text] [PDF]

				T. Thum and J. Bauersachs Spotlight on endothelial progenitor cell inhibitors: short review Vascular Medicine, May 1, 2005; 10(2_suppl): S59 - S64. [Abstract] [PDF]

				D. J. Wexler, R. W. Grant, J. B. Meigs, D. M. Nathan, and E. Cagliero Sex Disparities in Treatment of Cardiac Risk Factors in Patients With Type 2 Diabetes Diabetes Care, March 1, 2005; 28(3): 514 - 520. [Abstract] [Full Text] [PDF]

				S. B. Wheatcroft, A. M. Shah, J.-M. Li, E. Duncan, B. T. Noronha, P. A. Crossey, and M. T. Kearney Preserved Glucoregulation but Attenuation of the Vascular Actions of Insulin in Mice Heterozygous for Knockout of the Insulin Receptor Diabetes, October 1, 2004; 53(10): 2645 - 2652. [Abstract] [Full Text] [PDF]

				C.-Y. Xiao, M. Chen, Z. Zsengeller, and C. Szabo Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 498 - 504. [Abstract] [Full Text] [PDF]

				T. Kadowaki and N. Kubota Protective Role of Imatinib in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 801 - 803. [Full Text]