 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
4 April 2000 | Volume 132 Issue 7 | Pages 552-555
Background: Abnormal heart rate recovery after symptom-limited exercise predicts death. It is unknown whether this is also true among patients undergoing submaximal testing.
Objective: To test the prognostic implications of heart rate recovery in cardiovascularly healthy adults undergoing submaximal exercise testing.
Design: Population-based cohort study.
Setting: 10 primary care sites.
Participants: 5234 adults without evidence of cardiovascular disease who were enrolled in the Lipid Research Clinics Prevalence Study.
Measurements: Heart rate recovery was defined as the change from peak heart rate to that measured 2 minutes later (heart rate recovery was defined as
Results: During 12 years of follow-up, 312 participants died. Abnormal heart rate recovery predicted death (relative risk, 2.58 [CI, 2.06 to 3.20]). After adjustment for standard risk factors, fitness, and resting and exercise heart rates, abnormal heart rate recovery remained predictive (adjusted relative risk, 1.55 [CI, 1.22 to 1.98]) (P < 0.001).
Conclusion: Even after submaximal exercise, abnormal heart rate recovery predicts death.
Author and Article Information
From Cleveland Clinic Foundation, Cleveland, Ohio.
Disclaimer: This paper uses data supplied by the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services. The views expressed in this paper are those of the authors and do not necessarily reflect the views of the National Heart, Lung, and Blood Institute.
Grant Support: Dr. Lauer is the recipient of an Established Investigator Grant from the American Heart Association.
Requests for Single Reprints: Michael S. Lauer, MD, Desk F25, Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail, lauerm{at}ccf.org.
Requests To Purchase Bulk Reprints (minimum, 100 copies): the Reprints Coordinator; phone, 215-351-2657; e-mail, reprints{at}mail.acponline.org.
Current Author Addresses: Drs. Cole and Foody: Desk F15, Department of Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
Dr. Blackstone: Desk F25, Departments of Cardiothoracic Surgery and Epidemiology and Biostatistics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
Dr. Lauer: Desk F25, Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195.
Author Contributions: Conception and design: C.R. Cole, M.S. Lauer.
Analysis and interpretation of the data: C.R. Cole, J.M. Foody, E.H. Blackstone, M.S. Lauer.
Drafting of the article: C.R. Cole, J.M. Foody, M.S. Lauer.
Critical revision of the article for important intellectual content: C.R. Cole, J.M. Foody, E.H. Blackstone, M.S. Lauer.
Final approval of the article: C.R. Cole, J.M. Foody, E.H. Blackstone, M.S. Lauer.
Statistical expertise: E.H. Blackstone, M.S. Lauer.
Obtaining of funding: M.S. Lauer.
Administrative, technical, or logistic support: J.M. Foody.
Collection and assembly of data: C.R. Cole, J.M. Foody, M.S. Lauer. BRIEF COMMUNICATION
Heart Rate Recovery after Submaximal Exercise Testing as a Predictor of Mortality in a Cardiovascularly Healthy Cohort
42 beats/min).
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  T. A. Dawson, D. Li, T. Woodward, Z. Barber, L. Wang, and D. J. Paterson Cardiac cholinergic NO-cGMP signaling following acute myocardial infarction and nNOS gene transfer Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H990 - H998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. LAUER and T. D. MILLER The exercise treadmill test: Estimating cardiovascular prognosis Cleveland Clinic Journal of Medicine, June 1, 2008; 75(6): 424 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Lahiri, P. J. Kannankeril, and J. J. Goldberger Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications. J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1725 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sundaram, M. Carnethon, K. Polito, A. H. Kadish, and J. J. Goldberger Autonomic effects on QT-RR interval dynamics after exercise Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H490 - H497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Spielmann, A. S. Leon, D. C. Rao, T. Rice, J. S. Skinner, T. Rankinen, and C. Bouchard Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3366 - H3371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Dewland, A. S. Androne, F. A. Lee, R. J. Lampert, and S. D. Katz Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H86 - H92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Hautala, T. Rankinen, A. M. Kiviniemi, T. H. Makikallio, H. V. Huikuri, C. Bouchard, and M. P. Tulppo Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H459 - H466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Goldberger, F. K. Le, M. Lahiri, P. J. Kannankeril, J. Ng, and A. H. Kadish Assessment of parasympathetic reactivation after exercise Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2446 - H2452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Newman, E. M. Simonsick, B. L. Naydeck, R. M. Boudreau, S. B. Kritchevsky, M. C. Nevitt, M. Pahor, S. Satterfield, J. S. Brach, S. A. Studenski, et al. Association of Long-Distance Corridor Walk Performance With Mortality, Cardiovascular Disease, Mobility Limitation, and Disability JAMA, May 3, 2006; 295(17): 2018 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mora, R. F. Redberg, A. R. Sharrett, and R. S. Blumenthal Enhanced Risk Assessment in Asymptomatic Individuals With Exercise Testing and Framingham Risk Scores Circulation, September 13, 2005; 112(11): 1566 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Ricardo, M. B. de Almeida, B. A. Franklin, and C. G. S. Araujo Initial and Final Exercise Heart Rate Transients: Influence of Gender, Aerobic Fitness, and Clinical Status Chest, January 1, 2005; 127(1): 318 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Morise Heart Rate Recovery: Predictor of Risk Today and Target of Therapy Tomorrow? Circulation, November 2, 2004; 110(18): 2778 - 2780. [Full Text] [PDF]
|
|
|
|
|
|
L. W. Raymond Vagal Pas de Deux: Heart-Lung Interplay in Postexercise Heart Rate Recovery Chest, April 1, 2004; 125(4): 1186 - 1190. [Full Text] [PDF]
|
|
|
|
|
|
N. Seshadri, T. R. Gildea, K. McCarthy, C. Pothier, M. S. Kavuru, and M. S. Lauer Association of an Abnormal Exercise Heart Rate Recovery With Pulmonary Function Abnormalities Chest, April 1, 2004; 125(4): 1286 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Shishehbor, B. J. Hoogwerf, and M. S. Lauer Association of Triglyceride-to-HDL Cholesterol Ratio With Heart Rate Recovery Diabetes Care, April 1, 2004; 27(4): 936 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Yawn, K. A. Ammar, R. Thomas, and P. C. Wollan Test-Retest Reproducibility of Heart Rate Recovery After Treadmill Exercise Ann. Fam. Med, November 1, 2003; 1(4): 236 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Carnethon, D. R. Jacobs Jr., S. Sidney, and K. Liu Influence of Autonomic Nervous System Dysfunction on the Development of Type 2 Diabetes: The CARDIA study Diabetes Care, November 1, 2003; 26(11): 3035 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mora, R. F. Redberg, Y. Cui, M. K. Whiteman, J. A. Flaws, A. R. Sharrett, and R. S. Blumenthal Ability of Exercise Testing to Predict Cardiovascular and All-Cause Death in Asymptomatic Women: A 20-Year Follow-up of the Lipid Research Clinics Prevalence Study JAMA, September 24, 2003; 290(12): 1600 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Vivekananthan, E. H. Blackstone, C. E. Pothier, and M. S. Lauer Heart rate recovery after exercise is apredictor of mortality, independent of the angiographic severity of coronary disease J. Am. Coll. Cardiol., September 3, 2003; 42(5): 831 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Chaitman Abnormal heart rateresponses to exercise predict increased long-term mortality regardless of coronary disease extent: The question is why? J. Am. Coll. Cardiol., September 3, 2003; 42(5): 839 - 841. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Panzer, M. S. Lauer, A. Brieke, E. Blackstone, and B. Hoogwerf Association of Fasting Plasma Glucose With Heart Rate Recovery in Healthy Adults: A Population-Based Study Diabetes, March 1, 2002; 51(3): 803 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shetler, R. Marcus, V. F. Froelicher, S. Vora, D. Kalisetti, M. Prakash, D. Do, and J. Myers Heart rate recovery: validation and methodologic issues J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1980 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Watanabe, M. Thamilarasan, E. H. Blackstone, J. D. Thomas, and M. S. Lauer Heart Rate Recovery Immediately After Treadmill Exercise and Left Ventricular Systolic Dysfunction as Predictors of Mortality: The Case of Stress Echocardiography Circulation, October 16, 2001; 104(16): 1911 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Diaz, R. C. Brunken, E. H. Blackstone, C. E. Snader, and M. S. Lauer Independent contribution of myocardial perfusion defects to exercise capacity and heart rate recovery for prediction of all-cause mortality in patients with known or suspected coronary heart disease J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1558 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Nishime, C. R. Cole, E. H. Blackstone, F. J. Pashkow, and M. S. Lauer Heart Rate Recovery and Treadmill Exercise Score as Predictors of Mortality in Patients Referred for Exercise ECG JAMA, September 20, 2000; 284(11): 1392 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kannankeril and J. J. Goldberger Parasympathetic effects on cardiac electrophysiology during exercise and recovery Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2091 - H2098. [Abstract] [Full Text] [PDF]
|
|
Article
