Article    Table of Contents                    Full Text of this article    PDF of this article (PDFs free after 6 months)    Figures/Tables List  Services    Send comment/rapid response letter    Notify a friend about this article    Alert me when this article is cited    Add to Personal Archive    Download to Citation Manager    ACP Search                            Get Permissions  Google Scholar    Search for Related Content  PubMed Articles in PubMed by Author:    Adams, J. S.    Kantorovich, V.    Related Articles in PubMed    PubMed Citation    PubMed

BRIEF COMMUNICATION

Rapid Recovery of Bone Mass in Hypercalciuric, Osteoporotic Men Treated with Hydrochlorothiazide

John S. Adams, MD; Cindy F. Song, BS; and Vitaly Kantorovich, MD

20 April 1999 | Volume 130 Issue 8 | Pages 658-660

Background: Chronic hypercalciuria can contribute to osteoporosis, particularly in men.

Objective: To ascertain the effects of resolution of hypercalciuria on bone mineral density.

Design: Case series.

Setting: Referral service for metabolic bone disease in a tertiary-care teaching hospital.

Patients: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.

Intervention: Hydrochlorothiazide, 25 mg twice daily, for a mean (± SD) of 7.8 ± 3.6 months.

Measurements: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.

Results: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.

Conclusions: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.

Author and Article Information

From Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine, Los Angeles, California.

Grant Support: In part by grant MO1-RR00425 from the National Center for Research Resources and the National Institutes of Health General Clinical Research Center.

Requests for Reprints: John S. Adams, MD, B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048; e-mail, adamsj{at}cshs.org.

Current Author Addresses: Dr. Adams: B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.

Ms. Song: 491 11th Avenue, San Francisco, CA 94118.

Dr. Kantorovich: B-131, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048.

This article has been cited by other articles:

				S. Khosla, S. Amin, and E. Orwoll Osteoporosis in Men Endocr. Rev., June 1, 2008; 29(4): 441 - 464. [Abstract] [Full Text] [PDF]

				H. Belge, P. Gailly, B. Schwaller, J. Loffing, H. Debaix, E. Riveira-Munoz, R. Beauwens, J.-P. Devogelaer, J. G. Hoenderop, R. J. Bindels, et al. Renal expression of parvalbumin is critical for NaCl handling and response to diuretics PNAS, September 11, 2007; 104(37): 14849 - 14854. [Abstract] [Full Text] [PDF]

				J. L. Geller and J. S. Adams Statins and fracture: are all variables accounted for? Arch Intern Med, May 8, 2006; 166(9): 1041 - 1041. [Full Text] [PDF]

				R. E. Scranton, E. Lawler, M. Young, and J. M. Gaziano Statins and Fracture: Are All Variables Accounted For?--Reply Arch Intern Med, May 8, 2006; 166(9): 1041 - 1042. [Full Text] [PDF]

				M. W.C.J. Schoofs, M. van der Klift, A. Hofman, C. E.D.H. de Laet, R. M.C. Herings, T. Stijnen, H. A.P. Pols, and B. H.Ch. Stricker Thiazide Diuretics and the Risk for Hip Fracture Ann Intern Med, September 16, 2003; 139(6): 476 - 482. [Abstract] [Full Text] [PDF]

				D. N. Cruz The renal tubular Na-Cl co-transporter (NCCT): a potential genetic link between blood pressure and bone density? Nephrol. Dial. Transplant., April 1, 2001; 16(4): 691 - 694. [Full Text] [PDF]

				M. Thearle, M. Horlick, J. P. Bilezikian, J. Levy, J. M. Gertner, L. S. Levine, M. Harbison, W. Berdon, and S. E. Oberfield Osteoporosis: An Unusual Presentation of Childhood Crohn's Disease J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2122 - 2126. [Abstract] [Full Text]

				I. P. Heilberg Update on dietary recommendations and medical treatment of renal stone disease Nephrol. Dial. Transplant., January 1, 2000; 15(1): 117 - 123. [Full Text] [PDF]

				J. S. Adams, V. Kantorovich, C. Wu, M. Javanbakht, and B. W. Hollis Resolution of Vitamin D Insufficiency in Osteopenic Patients Results in Rapid Recovery of Bone Mineral Density J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2729 - 2730. [Abstract] [Full Text]