 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
16 February 1999 | Volume 130 Issue 4 Part 1 | Pages 278-284
Background: Previous reports have suggested an association between birthweight and type 2 diabetes mellitus.
Objective: To investigate the association between birthweight and type 2 diabetes in a large cohort of adult women, taking into account potential explanatory factors in childhood and adult life.
Design: Cohort study. Birthweight was ascertained at the end of follow-up.
Setting: The Nurses' Health Study, a cohort of 121 701 U.S. women born from 1921 to 1946 who have been followed since 1976.
Participants: 69 526 women in the Nurses' Health Study who were free of diabetes at baseline and reported their own birthweight on the 1992 questionnaire.
Measurement: 2123 cases of confirmed type 2 diabetes diagnosed from 1976 to 1992.
Results: Low birthweight was associated with increased risk for type 2 diabetes. Age-adjusted relative risks suggested a reverse J-shape association between birthweight and risk for type 2 diabetes. However, after adjustment for adult body mass index and maternal history of diabetes, an inverse association across the entire range of birthweight became apparent; compared with the reference group, relative risks by ascending birthweight category were 1.83 (95% CI, 1.55 to 2.16) for birthweight less than 5.0 lb, 1.76 (CI, 1.49 to 2.07) for birthweight 5.0 to 5.5 lb, 1.23 (CI, 1.11 to 1.37) for birthweight 5.6 to 7.0 lb, 0.95 (CI, 0.82 to 1.10) for birthweight 8.6 to 10.0 lb, and 0.83 (CI, 0.63 to 1.07) for birthweight of more than 10 lb (P for trend < 0.001). Adjustment for ethnicity, childhood socioeconomic status, and adult lifestyle factors did not substantially alter this association. The association between birthweight and risk for type 2 diabetes was strongest among women whose mothers had no history of diabetes.
Conclusions: Birthweight is inversely associated with risk for type 2 diabetes during adulthood. Examination of prenatal nutrition and other potential in utero determinants of both birthweight and risk for type 2 diabetes may yield new means to prevent type 2 diabetes.
Author and Article Information
Acknowledgments: The authors thank the participants in the Nurses' Health Study for their dedication and Gary Chase, Karen Corsano, Barbara Egan, Maureen Johnston, and Mark Shneyder for their excellent work.
Grant Support: The Nurses' Health Study is supported by research grants DK36798 and CA 40356 from the National Institutes of Health.
Requests for Reprints: Janet W. Rich-Edwards, DSc, Nurses' Health Study, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115.
Current Author Addresses: Drs. Rich-Edwards and Gillman: Department of Ambulatory Care and Prevention, 126 Brookline Avenue, Suite 200, Boston, MA 02115.
Drs. Colditz, Stampfer, Willett, Speizer, and Manson: Nurses' Health Study, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115.
Dr. Hennekens: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215. ARTICLE
Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  J. S. Cnossen MD, R. K. Morris MD, G. ter Riet MD PhD, B. W.J. Mol MD PhD, J. A.M. van der Post MD PhD, A. Coomarasamy MD, A. H. Zwinderman MSc PhD, S. C. Robson MD, P. J.E. Bindels MD PhD, J. Kleijnen MD PhD, et al. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis Can. Med. Assoc. J., March 11, 2008; 178(6): 701 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Xue, W. C. Willett, B. A. Rosner, M. R. Forman, and K. B. Michels Parental characteristics as predictors of birthweight Hum. Reprod., January 1, 2008; 23(1): 168 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Al Salmi, W. E. Hoy, S. Kondalsamy-Chennakesavan, Z. Wang, G. C. Gobe, E. L. M. Barr, and J. E. Shaw Disorders of Glucose Regulation in Adults and Birth Weight: Results from the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study Diabetes Care, January 1, 2008; 31(1): 159 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Signorello, D. G. Schlundt, S. S. Cohen, M. D. Steinwandel, M. S. Buchowski, J. K. McLaughlin, M. K. Hargreaves, and W. J. Blot Comparing Diabetes Prevalence Between African Americans and Whites of Similar Socioeconomic Status Am J Public Health, December 1, 2007; 97(12): 2260 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Spence, F. A Alderdice, M. C Stewart, H. L Halliday, and A. H Bell Does intrauterine growth restriction affect quality of life in adulthood? Arch. Dis. Child., August 1, 2007; 92(8): 700 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Pettitt and L. Jovanovic Low Birth Weight as a Risk Factor for Gestational Diabetes, Diabetes, and Impaired Glucose Tolerance During Pregnancy Diabetes Care, July 1, 2007; 30(Supplement_2): S147 - S149. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pfab, M. Godes, B. Hocher, T. Slowinski, H. Halle, and F. Priem Response to Letter Regarding Article, "Low Birth Weight, a Risk Factor for Cardiovascular Diseases in Later Life, Is Already Associated With Elevated Fetal Glycosylated Hemoglobin at Birth" Circulation, May 15, 2007; 115(19): e463 - e464. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Harder, E. Rodekamp, K. Schellong, J. W. Dudenhausen, and A. Plagemann Birth Weight and Subsequent Risk of Type 2 Diabetes: A Meta-Analysis Am. J. Epidemiol., April 15, 2007; 165(8): 849 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meirhaeghe, C. A.G. Boreham, L. J. Murray, F. Richard, G. D. Smith, I. S. Young, and P. Amouyel A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth Diabetes, February 1, 2007; 56(2): 494 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C R Chittleborough, F E Baum, A W Taylor, and J E Hiller A life-course approach to measuring socioeconomic position in population health surveillance systems. J. Epidemiol. Community Health, November 1, 2006; 60(11): 981 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C J R Goddard and H R Gillett Complications of coeliac disease: are all patients at risk? Postgrad. Med. J., November 1, 2006; 82(973): 705 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pfab, T. Slowinski, M. Godes, H. Halle, F. Priem;, and B. Hocher Low Birth Weight, a Risk Factor for Cardiovascular Diseases in Later Life, Is Already Associated With Elevated Fetal Glycosylated Hemoglobin at Birth Circulation, October 17, 2006; 114(16): 1687 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Tian, Q. Cheng, X.-M. Song, G. Li, G.-X. Jiang, Y.-Y. Gu, and M. Luo Birth weight and risk of type 2 diabetes, abdominal obesity and hypertension among Chinese adults. Eur. J. Endocrinol., October 1, 2006; 155(4): 601 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Segar, R. D. Roghair, E. M. Segar, M. C. Bailey, T. D. Scholz, and F. S. Lamb Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R481 - R488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Franks, H. C. Looker, S. Kobes, L. Touger, P. A. Tataranni, R. L. Hanson, and W. C. Knowler Gestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring Diabetes, February 1, 2006; 55(2): 460 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Leibson, J. P. Burke, J. E. Ransom, J. Forsgren, J. Melton III, K. R. Bailey, and P. J. Palumbo Relative Risk of Mortality Associated With Diabetes as a Function of Birth Weight Diabetes Care, December 1, 2005; 28(12): 2839 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Krishnaveni, J. C. Hill, S. D. Leary, S. R. Veena, J. Saperia, A. Saroja, S. C. Karat, and C. H.D. Fall Anthropometry, Glucose Tolerance, and Insulin Concentrations in Indian Children: Relationships to maternal glucose and insulin concentrations during pregnancy Diabetes Care, December 1, 2005; 28(12): 2919 - 2925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W A Shultis, S D Leary, A R Ness, C J Bain, P M Emmett, and and the ALSPAC Study Team Does birth weight predict childhood diet in the Avon longitudinal study of parents and children? J. Epidemiol. Community Health, November 1, 2005; 59(11): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J.P. Barker and S. P. Bagby Developmental Antecedents of Cardiovascular Disease: A Historical Perspective J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2537 - 2544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Simmons, I. Suponitsky-Kroyter, and M. A. Selak Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to {beta}-Cell Failure J. Biol. Chem., August 5, 2005; 280(31): 28785 - 28791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S Sachdev, C. H. Fall, C. Osmond, R. Lakshmy, S. K Dey Biswas, S. D Leary, K. S. Reddy, D. J. Barker, and S. K Bhargava Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort Am. J. Clinical Nutrition, August 1, 2005; 82(2): 456 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Syddall, A. A. Sayer, S. J. Simmonds, C. Osmond, V. Cox, E. M. Dennison, D. J. P. Barker, and C. Cooper Birth Weight, Infant Weight Gain, and Cause-specific Mortality: The Hertfordshire Cohort Study Am. J. Epidemiol., June 1, 2005; 161(11): 1074 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Bazaes, V. Mericq, A. Plagemann, T. Harder, P. L. Hofman, and W. S. Cutfield Premature Birth and Insulin Resistance N. Engl. J. Med., March 3, 2005; 352(9): 939 - 940. [Full Text] [PDF]
|
|
|
|
|
|
L. Touger, H. C. Looker, J. Krakoff, R. S. Lindsay, V. Cook, and W. C. Knowler Early Growth in Offspring of Diabetic Mothers Diabetes Care, March 1, 2005; 28(3): 585 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Simmons Fetal Origins of Adult Disease: Concepts and Controversies NeoReviews, December 1, 2004; 5(12): e511 - e515. [Full Text] [PDF]
|
|
|
|
 |
|
 D.J.P. Barker The Developmental Origins of Adult Disease J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 588S - 595S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Burke, J. Forsgren, P. J. Palumbo, K. R. Bailey, J. Desai, H. Devlin, and C. L. Leibson Association of Birth Weight and Type 2 Diabetes in Rochester, Minnesota Diabetes Care, October 1, 2004; 27(10): 2512 - 2513. [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Lederman, S. R. Akabas, B. J. Moore, M. E. Bentley, B. Devaney, M. W. Gillman, M. S. Kramer, J. A. Mennella, A. Ness, and J. Wardle Summary of the Presentations at the Conference on Preventing Childhood Obesity, December 8, 2003 Pediatrics, October 1, 2004; 114(4/S1): 1146 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Brown, S. L. Ettner, J. Piette, M. Weinberger, E. Gregg, M. F. Shapiro, A. J. Karter, M. Safford, B. Waitzfelder, P. A. Prata, et al. Socioeconomic Position and Health among Persons with Diabetes Mellitus: A Conceptual Framework and Review of the Literature Epidemiol. Rev., July 1, 2004; 26(1): 63 - 77. [Full Text] [PDF]
|
|
|
|
|
|
P McCarron, G Davey Smith, and A T Hattersley Type 2 diabetes in grandparents and birth weight in offspring and grandchildren in the ALSPAC study J. Epidemiol. Community Health, June 1, 2004; 58(6): 517 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cianfarani, C. Martinez, A. Maiorana, G. Scire, G. L. Spadoni, and S. Boemi Adiponectin Levels Are Reduced in Children Born Small for Gestational Age and Are Inversely Related to Postnatal Catch-Up Growth J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1346 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bhargava, H. S. Sachdev, C. H.D. Fall, C. Osmond, R. Lakshmy, D. J.P. Barker, S. K. D. Biswas, S. Ramji, D. Prabhakaran, and K. S. Reddy Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood N. Engl. J. Med., February 26, 2004; 350(9): 865 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. E. Peterside, M. A. Selak, and R. A. Simmons Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1258 - E1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Freemark Pharmacologic Approaches to the Prevention of Type 2 Diabetes in High Risk Pediatric Patients J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 3 - 13. [Full Text] [PDF]
|
|
|
|
|
|
J. G. Eriksson, V. Lindi, M. Uusitupa, T. J. Forsen, M. Laakso, C. Osmond, and D. J.P. Barker The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth Diabetes, July 1, 2002; 51(7): 2321 - 2324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Innes, T. E. Byers, J. A. Marshall, A. Baron, M. Orleans, and R. F. Hamman Association of a Woman's Own Birth Weight With Subsequent Risk for Gestational Diabetes JAMA, May 15, 2002; 287(19): 2534 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Jensen, H. Storgaard, F. Dela, J. J. Holst, S. Madsbad, and A. A. Vaag Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight Diabetes, April 1, 2002; 51(4): 1271 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C N. Hales and D. J P Barker The thrifty phenotype hypothesis: Type 2 diabetes Br. Med. Bull., November 1, 2001; 60(1): 5 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H D Fall Non-industrialised countries and affluence: Relationship with Type 2 diabetes Br. Med. Bull., November 1, 2001; 60(1): 33 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Eriksson, J. Lindstrom, and J. Tuomilehto Potential for the prevention of type 2 diabetes Br. Med. Bull., November 1, 2001; 60(1): 183 - 199. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Forsen, J. Eriksson, J. Tuomilehto, A. Reunanen, C. Osmond, and D. Barker The Fetal and Childhood Growth of Persons Who Develop Type 2 Diabetes Ann Intern Med, August 1, 2000; 133(3): 176 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J.P. Barker The Fetal Origins of Type 2 Diabetes Mellitus Ann Intern Med, February 16, 1999; 130(4_Part_1): 322 - 324. [Full Text] [PDF]
|
|
Article
