 |
 |
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
18 May 1999 | Volume 130 Issue 10 | Pages 841-847
The past decade has witnessed a dramatic expansion in the scope of both mechanical and pharmacologic methods for opening occluded arteries in patients with acute myocardial infarction. Although the relative merits of conventional balloon angioplasty and thrombolysis have been evaluated, this old debate is being eclipsed by new comparisons. New device technologies, such as intracoronary stenting; more potent and more fibrin-specific thrombolytic agents; and new antithrombotic and antiplatelet agents all offer the potential for improved outcomes. But despite these recent developments, the time-dependent open artery hypothesis—which states that the achievement of early, full, and sustained reperfusion is associated with better outcomes—remains essentially unchanged. This article reviews data on the ability of six revascularization strategies—stand-alone thrombolysis, conventional percutaneous transluminal coronary angioplasty, stenting, glycoprotein IIb/IIIa inhibitors plus thrombolytic agents, glycoprotein IIb/IIIa inhibitors plus interventions, and the combination of pharmacologic and mechanical interventions—to produce early, full, and sustained reperfusion.
Author and Article Information
From Allegheny General Hospital, Pittsburgh, Pennsylvania.
Requests for Reprints: C. Michael Gibson, MS, MD, Invasive Cardiology, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212. UPDATE
Primary Angioplasty Compared with Thrombolysis: New Issues in the Era of Glycoprotein IIb/IIIa Inhibition and Intracoronary Stenting
This article has been cited by other articles:
|
|
 |
|
  S. S. Patel, H. Rana, and D. A. N. Mascarenhas Intracoronary Abciximab Use in Patients Undergoing PCI at a Community Hospital: A Single Operator Experience Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2008; 13(2): 89 - 93. [Abstract] [PDF]
|
|
|
|
 |
|
 M. R. Le May, G. A. Wells, M. Labinaz, R. F. Davies, M. Turek, D. Leddy, J. Maloney, T. McKibbin, B. Quinn, R. S. Beanlands, et al. Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study) J. Am. Coll. Cardiol., August 2, 2005; 46(3): 417 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Aschermann and P. Widimsky I have an acute myocardial infarction: open my coronary artery, stent it and keep full flow! Eur. Heart J., June 2, 2002; 23(12): 913 - 916. [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Armstrong New advances in the management of acute coronary syndromes: 2. Fibrinolytic therapy for acute ST-segment elevation myocardial infarction Can. Med. Assoc. J., September 1, 2001; 165(6): 791 - 797. [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Armstrong and D. Collen Fibrinolysis for Acute Myocardial Infarction : Current Status and New Horizons for Pharmacological Reperfusion, Part 2 Circulation, June 19, 2001; 103(24): 2987 - 2992. [Full Text] [PDF]
|
|
|
|
 |
|
 H.C. Herrmann, R.H. Li, and E.M. Ohman Facilitated percutaneous coronary intervention: results from the SPEED trial Eur. Heart J. Suppl., May 1, 2001; 3(suppl_A): A26 - A34. [Abstract] [PDF]
|
|
|
|
|
|
H. C. Herrmann, D. J. Moliterno, E. M. Ohman, A. L. Stebbins, C. Bode, A. Betriu, F. Forycki, J. S. Miklin, W. B. Bachinsky, A. M. Lincoff, et al. Facilitation of early percutaneous coronary intervention after reteplase with or without abciximab in acute myocardial infarction: Results from the SPEED (GUSTO-4 Pilot) trial J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1489 - 1496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Gibson A union in reperfusion:: The concept of facilitated percutaneous coronary intervention J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1497 - 1499. [Full Text] [PDF]
|
|
Article
