 |
 |
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
15 September 1997 | Volume 127 Issue 6 | Pages 423-428
Background: Several studies from Europe have reported a high prevalence (9% to 32%) of chronic hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin lymphoma. It has been suggested that HCV plays a role in the pathogenesis of B-cell non-Hodgkin lymphoma.
Objective: To determine the prevalence of HCV infection in patients with B-cell lymphoma in the United States.
Design: Controlled, cross-sectional analysis.
Setting: University medical center.
Patients: 120 patients with B-cell lymphoma (78% were Hispanic, 9% were black, 7% were Asian, and 6% were white), 154 patients with other malignant hematologic conditions (control group 1), and 114 patients with nonmalignant conditions (control group 2).
Measurements: Samples were tested for antibodies to HCV by enzyme-linked immunosorbent assay. Hepatitis C virus RNA was detected by reverse-transcription polymerase chain reaction. Genotyping for HCV was done with genotype-specific primers from the HCV core region.
Results: Infection with HCV was detected in 26 patients (22% [95% CI, 15% to 30%]) with B-cell lymphoma compared with 7 of 154 patients (4.5%) in control group 1 and 6 of 114 patients (5%) in control group 2 (P < 0.001). Risk factors for HCV infection were present in 15 patients (60%) with B-cell lymphoma and occurred a median of 15 years before diagnosis of lymphoma. Monocytoid B-cell lymphoma was the most common type of lymphoma found in HCV-positive patients (23% compared with 7% in HCV-negative patients) (P = 0.034).
Conclusions: The prevalence of HCV infection was higher in patients with B-cell non-Hodgkin lymphoma than in controls. The possible role of HCV in the pathogenesis of B-cell lymphoma warrants further investigation.
Author and Article Information
From University of Southern California School of Medicine, Los Angeles, California; Roche Molecular Systems, Somerville, New Jersey; and Nagoya City University Medical School, Nagoya, Japan.
ARTICLE
Hepatitis C Virus Infection in Patients with B-Cell Non-Hodgkin Lymphoma
Acknowledgment: The authors thank Gus Miranda for technical assistance.
Note: Drs. E. Zuckerman and T. Zuckerman contributed equally to this paper.
Grant Support: In part by the Lymphoma Research Foundation of America, Inc.
Requests for Reprints: Eli Zuckerman, MD, Department of Internal Medicine A, B'nai Zion Medical Center, 47 Golomb Street, Box 4940, Haifa 31048, Israel.
Current Author Addresses: Dr. E. Zuckerman: Department of Internal Medicine A, B'nai Zion Medical Center, 47 Golomb Street, Box 4940, Haifa 31048, Israel.
This article has been cited by other articles:
|
|
 |
|
  K. Machida, Y. Kondo, J. Y. Huang, Y.-C. Chen, K. T.-H. Cheng, Z. Keck, S. Foung, J. Dubuisson, V. M.-H. Sung, and M. M. C. Lai Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein J. Virol., July 1, 2008; 82(13): 6711 - 6720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Beaty, A. C. Silva, and G. DePetris AJR Teaching File: Incidental Hepatic Mass Am. J. Roentgenol., June 1, 2008; 190(6_Supplement): S62 - S64. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Saadoun, D. A. Landau, L. H. Calabrese, and P. P. Cacoub Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation Rheumatology, August 1, 2007; 46(8): 1234 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bianchettin, C. Bonaccini, R. Oliva, A. Tramontano, A. Cividini, M. Casato, G. Merlini, E. Silini, and M. U. Mondelli Analysis of Hepatitis C Virus Hypervariable Region 1 Sequence from Cryoglobulinemic Patients and Associated Controls J. Virol., May 1, 2007; 81(9): 4564 - 4571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ferreri, R Dolcetti, P Musto, G. Dognini, C Doglioni, and M Ponzoni Reply to the article 'Hepatitis C virus (HCV) infection and MALT-type ocular adnexal lymphoma (OAL)' by P. Arnaud, M.-C. Escande, M. Lecuit et al. (Ann Oncol doi:10.1093/annonc/mdl369) Ann. Onc., February 1, 2007; 18(2): 401 - 403. [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. McGinnis, S. L. Fultz, M. Skanderson, J. Conigliaro, K. Bryant, and A. C. Justice Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse J. Clin. Oncol., November 1, 2006; 24(31): 5005 - 5009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dal Maso and S. Franceschi Hepatitis C Virus and Risk of Lymphoma and Other Lymphoid Neoplasms: A Meta-analysis of Epidemiologic Studies. Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2078 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Visco, L Arcaini, E Brusamolino, S Burcheri, A Ambrosetti, M Merli, E Bonoldi, M Chilosi, A Viglio, M Lazzarino, et al. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy Ann. Onc., September 1, 2006; 17(9): 1434 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation Blood, April 15, 2006; 107(8): 3034 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Racanelli, M. A. Frassanito, P. Leone, M. Galiano, V. De Re, F. Silvestris, and F. Dammacco Antibody Production and In Vitro Behavior of CD27-Defined B-Cell Subsets: Persistent Hepatitis C Virus Infection Changes the Rules. J. Virol., April 1, 2006; 80(8): 3923 - 3934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Besson, D. Canioni, E. Lepage, S. Pol, P. Morel, P. Lederlin, A. Van Hoof, H. Tilly, P. Gaulard, B. Coiffier, et al. Characteristics and Outcome of Diffuse Large B-Cell Lymphoma in Hepatitis C Virus-Positive Patients in LNH 93 and LNH 98 Groupe d'Etude des Lymphomes de l'Adulte Programs J. Clin. Oncol., February 20, 2006; 24(6): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Firpi and D. R. Nelson Viral Hepatitis: Manifestations and Management Strategy Hematology, January 1, 2006; 2006(1): 375 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Svec, M H Ward, M Dosemeci, H Checkoway, and A J De Roos Risk of lymphatic or haematopoietic cancer mortality with occupational exposure to animals or the public Occup. Environ. Med., October 1, 2005; 62(10): 726 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zehender, C. De Maddalena, F. Bernini, E. Ebranati, G. Monti, P. Pioltelli, and M. Galli Compartmentalization of Hepatitis C Virus Quasispecies in Blood Mononuclear Cells of Patients with Mixed Cryoglobulinemic Syndrome J. Virol., July 15, 2005; 79(14): 9145 - 9156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vallisa, P. Bernuzzi, L. Arcaini, S. Sacchi, V. Callea, R. Marasca, A. Lazzaro, E. Trabacchi, E. Anselmi, A. L. Arcari, et al. Role of Anti-Hepatitis C Virus (HCV) Treatment in HCV-Related, Low-Grade, B-Cell, Non-Hodgkin's Lymphoma: A Multicenter Italian Experience J. Clin. Oncol., January 20, 2005; 23(3): 468 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Saadoun, F. Suarez, F. Lefrere, F. Valensi, X. Mariette, A. Aouba, C. Besson, B. Varet, X. Troussard, P. Cacoub, et al. Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity? Blood, January 1, 2005; 105(1): 74 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D Cowgill, C. A Loffredo, S. A.-L. Eissa, N. Mokhtar, M. Abdel-Hamid, A. Fahmy, and G T. Strickland Case-control study of non-Hodgkin's lymphoma and hepatitis C virus infection in Egypt Int. J. Epidemiol., October 1, 2004; 33(5): 1034 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Morton, E. A. Engels, T. R. Holford, B. Leaderer, Y. Zhang, S. H. Zahm, P. Boyle, B. Zhang, S. Flynn, G. Tallini, et al. Hepatitis C Virus and Risk of Non-Hodgkin Lymphoma: A Population-Based Case-Control Study among Connecticut Women Cancer Epidemiol. Biomarkers Prev., March 1, 2004; 13(3): 425 - 430. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. M. Levine, S. Shimodaira, and M. M.C. Lai Treatment of HCV-Related Mantle-Cell Lymphoma with Ribavirin and Pegylated Interferon Alfa N. Engl. J. Med., November 20, 2003; 349(21): 2078 - 2079. [Full Text] [PDF]
|
|
|
|
|
|
E. Zuckerman, A. Kessel, G. Slobodin, E. Sabo, D. Yeshurun, and E. Toubi Antiviral Treatment Down-Regulates Peripheral B-Cell CD81 Expression and CD5 Expansion in Chronic Hepatitis C Virus Infection J. Virol., October 1, 2003; 77(19): 10432 - 10436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Turner, G. Dusheiko, and A. Jones Hepatitis C and B-cell lymphoma Ann. Onc., September 1, 2003; 14(9): 1341 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mele, A. Pulsoni, E. Bianco, P. Musto, A. Szklo, M. G. Sanpaolo, E. Iannitto, A. De Renzo, B. Martino, V. Liso, et al. Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study Blood, August 1, 2003; 102(3): 996 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ni, E. Hembrador, A. M. Di Bisceglie, I. M. Jacobson, A. H. Talal, D. Butera, C. M. Rice, T. J. Chambers, and L. B. Dustin Accumulation of B Lymphocytes with a Naive, Resting Phenotype in a Subset of Hepatitis C Patients J. Immunol., March 15, 2003; 170(6): 3429 - 3439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Carrozzo and S. Gandolfo ORAL DISEASES POSSIBLY ASSOCIATEDWITH HEPATITIS C VIRUS Crit. Rev. Oral. Biol. Med., March 1, 2003; 14(2): 115 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M.-H. Sung, S. Shimodaira, A. L. Doughty, G. R. Picchio, H. Can, T. S. B. Yen, K. L. Lindsay, A. M. Levine, and M. M. C. Lai Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection J. Virol., February 1, 2003; 77(3): 2134 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hermine, F. Lefrere, J.-P. Bronowicki, X. Mariette, K. Jondeau, V. Eclache-Saudreau, B. Delmas, F. Valensi, P. Cacoub, C. Brechot, et al. Regression of Splenic Lymphoma with Villous Lymphocytes after Treatment of Hepatitis C Virus Infection N. Engl. J. Med., July 11, 2002; 347(2): 89 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Rabkin, B. H. Tess, R. E. Christianson, W. E. Wright, D. J. Waters, H. J. Alter, and B. J. van den Berg Prospective study of hepatitis C viral infection as a risk factor for subsequent B-cell neoplasia Blood, May 13, 2002; 99(11): 4240 - 4242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Ferri, A L Zignego, and S A Pileri Cryoglobulins J. Clin. Pathol., January 1, 2002; 55(1): 4 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X Mariette Lymphomas complicating Sjogren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells Ann Rheum Dis, November 1, 2001; 60(11): 1007 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Conconi, F. Bertoni, E. Pedrinis, T. Motta, E. Roggero, S. Luminari, C. Capella, M. Bonato, F. Cavalli, and E. Zucca Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes Blood, August 1, 2001; 98(3): 781 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Lauer and B. D. Walker Hepatitis C Virus Infection N. Engl. J. Med., July 5, 2001; 345(1): 41 - 52. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Marasca, P. Vaccari, M. Luppi, P. Zucchini, I. Castelli, P. Barozzi, A. Cuoghi, and G. Torelli Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma Am. J. Pathol., July 1, 2001; 159(1): 253 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zuckerman, T. Zuckerman, D. Sahar, S. Streichman, D. Attias, E. Sabo, D. Yeshurun, and J. M. Rowe The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection Blood, March 15, 2001; 97(6): 1555 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Longo, L. Potenza, N. D'Apollo, L. Ferrara, G. Gandini, M. Bertesi, G. Torelli, and G. Emilia Unusual Sites of Malignancy: Case 1. Primary Non-Hodgkin's Lymphoma of the Hand in a Patient With Hepatitis C Infection J. Clin. Oncol., March 1, 2001; 19(5): 1570 - 1572. [Full Text] [PDF]
|
|
|
|
|
|
Y. Kitay-Cohen, A. Amiel, N. Hilzenrat, D. Buskila, Y. Ashur, M. Fejgin, E. Gaber, R. Safadi, R. Tur-kaspa, and M. Lishner Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II Blood, October 15, 2000; 96(8): 2910 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Udomsakdi-Auewarakul, P. Auewarakul, S. Sukpanichnant, and W. Muangsup Hepatitis C virus infection in patients with non-Hodgkin lymphoma in Thailand Blood, June 1, 2000; 95(11): 3640 - 3641. [Full Text] [PDF]
|
|
|
|
|
|
G. Germanidis, C. Haioun, J. Pourquier, P. Gaulard, J.-M. Pawlotsky, D. Dhumeaux, and F. Reyes Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin's Lymphoma in a French Center Blood, March 1, 1999; 93(5): 1778 - 1779. [Full Text] [PDF]
|
|
|
|
|
|
D. L. Menkes, D. E. Palmer-Toy, and E T. Hedley-Whyte Case 3-1999- A 41-Year-Old Woman with Muscle Weakness, Painful Paresthesias, and Visual Problems N. Engl. J. Med., January 28, 1999; 340(4): 300 - 307. [Full Text] [PDF]
|
|
|
|
|
|
C. Antonescu, C. Mayerat, A. Mantegani, P. C. Frei, F. Spertini, and J.-D. Tissot Hepatitis C Virus (HCV) Infection: Serum Rheumatoid Factor Activity and HCV Genotype Correlate With Cryoglobulin Clonality Blood, November 1, 1998; 92(9): 3486 - 3488. [Full Text] [PDF]
|
|
|
|
|
|
D. Sansonno, S. De Vita, A. R. Iacobelli, V. Cornacchiulo, M. Boiocchi, and F. Dammacco Clonal Analysis of Intrahepatic B Cells from HCV-Infected Patients With and Without Mixed Cryoglobulinemia J. Immunol., April 1, 1998; 160(7): 3594 - 3601. [Abstract] [Full Text] [PDF]
|
|
Article
