Article    Table of Contents                    Full Text of this article Free    PDF of this article    Figures/Tables List  Services    Send comment/rapid response letter    Notify a friend about this article    Alert me when this article is cited    Add to Personal Archive    Download to Citation Manager    ACP Search    Get Permissions  Google Scholar    Search for Related Content  Social Bookmarking

What's this?

PubMed

Articles in PubMed by Author:    Shelhamer, J. H.    Rennard, S. I.    Related Articles in PubMed    PubMed Citation    PubMed

NIH CONFERENCE

Airway Inflammation

James H. Shelhamer; Stewart J. Levine; Tong Wu; David B. Jacoby; Michael A. Kaliner; and Stephen I. Rennard

15 August 1995 | Volume 123 Issue 4 | Pages 288-304

Diseases characterized by airway inflammation, excessive airway secretion, and airway obstruction affect a substantial proportion of the population.These diseases include asthma, chronic bronchitis, bronchiectasis, and cystic fibrosis. Asthma and chronic bronchitis may affect 25 million persons in the United States. Much progress has been made in the last decade toward an understanding of the mechanisms underlying chronic airway inflammation; recent work has resulted in several new concepts of the initiation and maintenance of airway inflammation. Airway production of chemokines, cytokines, and growth factors in response to irritants, infectious agents, and inflammatory mediators may play an important role in the modulation of acute and chronic airway inflammation. Lipid mediators may be produced by resident airway cells and by inflammatory cells; production of these mediators may also be altered by inflammatory cytokines. Increased airway obstruction may be related to intercurrent viral respiratory infection and to the induction of airway inflammation and airway hyperreactivity that results from such infection. Furthermore, several models exist to explain the processes by which airway inflammation is perpetuated in diseases such as asthma and chronic bronchitis. These include neurogenic inflammation, the perpetuation of the acute inflammatory response, and cycles of airway epithelial cell-mediated and inflammatory cell-mediated recruitment and activation of inflammatory cells. An understanding of these mechanisms of airway inflammation may provide the clinician with new therapeutic approaches to the treatment of these common and chronic diseases.

Author and Article Information

An edited summary of a Combined Clinical Staff Conference held on 27 April 1994 at the Clinical Center of the National Institutes of Health, Bethesda, Maryland.
Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of the reference:
Levine SJ. Bronchial epithelial cell-cytokine interactions in airway inflammation, pp 288-291. In: Shelhamer JH, moderator. Airway inflammation. Ann Intern Med. 1995; 123:288-304.
Requests for Reprints: James H. Shelhamer, MD, Building 10, Room 7-D-43, National Institutes of Health, Bethesda, MD 20892.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Facebook

Reddit

Technorati

Twitter

This article has been cited by other articles:

				W.-C. Chung, S.-H. Ryu, H. Sun, D. C. Zeldin, and J. S. Koo CREB Mediates Prostaglandin F2{alpha}-Induced MUC5AC Overexpression J. Immunol., February 15, 2009; 182(4): 2349 - 2356. [Abstract] [Full Text] [PDF]

				A. S. Sabnis, C. A. Reilly, J. M. Veranth, and G. S. Yost Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L194 - L200. [Abstract] [Full Text] [PDF]

				S. Katz, R. Harris, J. T.-Y. Lau, and A. Chau The use of gene expression analysis and proteomic databases in the development of a screening system to determine the value of natural medicinal products. Evid. Based Complement. Altern. Med., March 1, 2006; 3(1): 65 - 70. [Abstract] [Full Text] [PDF]

				ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005 Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 912 - 930. [Full Text] [PDF]

				R. Pawliczak, C. Han, X.-L. Huang, A. J. Demetris, J. H. Shelhamer, and T. Wu 85-kDa Cytosolic Phospholipase A2 Mediates Peroxisome Proliferator-activated Receptor gamma Activation in Human Lung Epithelial Cells J. Biol. Chem., August 30, 2002; 277(36): 33153 - 33163. [Abstract] [Full Text] [PDF]

				A. Weinbrenner, D. Huneke, M. Zschiesche, G. Engel, W. Timmer, V. W. Steinijans, T. Bethke, W. Wurst, A. Drollmann, H. J. Kaatz, et al. Circadian Rhythm of Serum Cortisol after Repeated Inhalation of the New Topical Steroid Ciclesonide J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2160 - 2163. [Abstract] [Full Text] [PDF]

				P. E. Silkoff, P. McClean, M. Spino, L. Erlich, A. S. Slutsky, and N. Zamel Dose-Response Relationship and Reproducibility of the Fall in Exhaled Nitric Oxide After Inhaled Beclomethasone Dipropionate Therapy in Asthma Patients Chest, May 1, 2001; 119(5): 1322 - 1328. [Abstract] [Full Text] [PDF]

				P. Cooper, S. Potter, B. Mueck, S. Yousefi, and G. Jarai Identification of genes induced by inflammatory cytokines in airway epithelium Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L841 - L852. [Abstract] [Full Text] [PDF]

				A. Coutts, G. Chen, N. Stephens, S. Hirst, D. Douglas, T. Eichholtz, and N. Khalil Release of biologically active TGF-{beta} from airway smooth muscle cells induces autocrine synthesis of collagen Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L999 - L1008. [Abstract] [Full Text] [PDF]

				P. E. Silkoff, D. Martin, J. Pak, J. Y. Westcott, and R. J. Martin Exhaled Nitric Oxide Correlated With Induced Sputum Findings in COPD Chest, April 1, 2001; 119(4): 1049 - 1055. [Abstract] [Full Text] [PDF]

				S. Tavakoli, M. J. Cowan, T. Benfield, C. Logun, and J. H. Shelhamer Prostaglandin E2-induced interleukin-6 release by a human airway epithelial cell line Am J Physiol Lung Cell Mol Physiol, January 1, 2001; 280(1): L127 - L133. [Abstract] [Full Text] [PDF]

				J. D. CRAPO, A. G. HARMSEN, M. P. SHERMAN, and R. A. MUSSON Pulmonary Immunobiology and Inflammation in Pulmonary Diseases Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1983 - 1986. [Full Text]

				G. Zhao, L. T. Vaszar, D. Qiu, L. Shi, and P. N. Kao Anti-inflammatory effects of triptolide in human bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L958 - L966. [Abstract] [Full Text] [PDF]

				H. A. Rotbart and F. G. Hayden Picornavirus Infections: A Primer for the Practitioner Arch Fam Med, September 1, 2000; 9(9): 913 - 920. [Abstract] [Full Text] [PDF]

				E. Moyse, M. Lyon, G. Cordier, J.-F. Mornex, L. Collet, and P. Froehlich Viral RNA in Middle Ear Mucosa and Exudates in Patients With Chronic Otitis Media With Effusion Arch Otolaryngol Head Neck Surg, September 1, 2000; 126(9): 1105 - 1110. [Abstract] [Full Text] [PDF]

				P. Silkoff Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children---1999 . THIS OFFICIAL STATEMENT OF THE AMERICAN THORACIC SOCIETY WAS ADOPTED BY THE ATS BOARD OF DIRECTORS, JULY 1999 Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2104 - 2117. [Full Text]

				Y. Aoki and P. N. Kao Erythromycin Inhibits Transcriptional Activation of NF-kappa B, but not NFAT, through Calcineurin-Independent Signaling in T Cells Antimicrob. Agents Chemother., November 1, 1999; 43(11): 2678 - 2684. [Abstract] [Full Text]

				E. Campbell, C. Hogaboam, P. Lincoln, and N. W. Lukacs Stem Cell Factor-Induced Airway Hyperreactivity in Allergic and Normal Mice Am. J. Pathol., April 1, 1999; 154(4): 1259 - 1265. [Abstract] [Full Text] [PDF]

				M. A. Olszewski, N. E. Robinson, F.-X. Zhu, X.-Y. Zhang, and P. K. Tithof Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways Am J Physiol Lung Cell Mol Physiol, March 1, 1999; 276(3): L522 - L529. [Abstract] [Full Text] [PDF]

				Y. Aoki, G. Zhao, D. Qiu, L. Shi, and P. N. Kao CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1164 - L1172. [Abstract] [Full Text] [PDF]

				Y. Aoki, D. Qiu, G. H. Zhao, and P. N. Kao Leukotriene B4 mediates histamine induction of NF-kappa B and IL-8 in human bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1030 - L1039. [Abstract] [Full Text] [PDF]

				Z. Jiang, M. Kunimoto, and J. A. Patel Autocrine Regulation and Experimental Modulation of Interleukin-6 Expression by Human Pulmonary Epithelial Cells Infected with Respiratory Syncytial Virus J. Virol., March 1, 1998; 72(3): 2496 - 2499. [Abstract] [Full Text] [PDF]

				A. TORRES, M. J. UTELL, P. E. MOROW, K. Z. VOTER, J. C. WHITIN, C. COX, R. JOHN LOONEY, D. M. SPEERS, Y. TSAI, and M. W. FRAMPTON Airway Inflammation in Smokers and Nonsmokers with Varying Responsiveness to Ozone Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 728 - 736. [Abstract] [Full Text] [PDF]

				T. G. Vondracek and W. F. Stanaszek The Pathophysiology of Asthma Journal of Pharmacy Practice, June 1, 1997; 10(3): 176 - 185. [Abstract] [PDF]