Article    Table of Contents                    Full Text of this article Free    Figures/Tables List  Services    Send comment/rapid response letter    Notify a friend about this article    Alert me when this article is cited    Add to Personal Archive    Download to Citation Manager    ACP Search                            Get Permissions  Google Scholar    Search for Related Content  PubMed Articles in PubMed by Author:    Gallin, J. I.    Nutman, T. B.    Related Articles in PubMed    PubMed Citation    PubMed

NIH CONFERENCE

Interferon- in the Management of Infectious Diseases

John I. Gallin; Joshua M. Farber; Steven M. Holland; and Thomas B. Nutman

1 August 1995 | Volume 123 Issue 3 | Pages 216-224

Interferon- has pleiotropic adjuvant effects on host defenses. These effects have made interferon- particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon- will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon- is emerging as an important cytokine for use in the treatment of infectious diseases.

Author and Article Information

An edited summary of a Combined Clinical Staff Conference held 30 March 1994 at the National Institutes of Health, Bethesda, Maryland.
Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference:
Farber JM. Mechanisms of action, pp 216-219. In: Gallin JI, moderator. Interferon- in the management of infectious diseases. Ann Intern Med. 1995; 123:216-224.
Requests for Reprints: John I. Gallin, MD, Warren G. Magnuson Clinical Center, National Institutes of Health, Building 10, Room 2C146, 10 Center Drive, MSC 1504, Bethesda, MD 20892-1504.

This article has been cited by other articles:

				T. V Piscopo and C. Mallia Azzopardi Leishmaniasis. Postgrad. Med. J., February 1, 2007; 83(976): 649 - 657. [Abstract] [Full Text] [PDF]

				T V Piscopo and A C Mallia Leishmaniasis. Postgrad. Med. J., October 1, 2006; 82(972): 649 - 657. [Abstract] [Full Text] [PDF]

				A. Di Stefano, G. Caramori, A. Capelli, I. Gnemmi, F.L. Ricciardolo, T. Oates, C.F. Donner, K.F. Chung, P.J. Barnes, and I.M. Adcock STAT4 activation in smokers and patients with chronic obstructive pulmonary disease Eur. Respir. J., July 1, 2004; 24(1): 78 - 85. [Abstract] [Full Text] [PDF]

				M. S. Lim and K. S.J. Elenitoba-Johnson The Molecular Pathology of Primary Immunodeficiencies J. Mol. Diagn., May 1, 2004; 6(2): 59 - 83. [Full Text] [PDF]

				O. Olakanmi, L. S. Schlesinger, A. Ahmed, and B. E. Britigan The Nature of Extracellular Iron Influences Iron Acquisition by Mycobacterium tuberculosis Residing within Human Macrophages Infect. Immun., April 1, 2004; 72(4): 2022 - 2028. [Abstract] [Full Text] [PDF]

				B. H. Segal, L. Ding, and S. M. Holland Phagocyte NADPH Oxidase, but Not Inducible Nitric Oxide Synthase, Is Essential for Early Control of Burkholderia cepacia and Chromobacterium violaceum Infection in Mice Infect. Immun., January 1, 2003; 71(1): 205 - 210. [Abstract] [Full Text] [PDF]

				K. M. Antoniou, E. Ferdoutsis, and D. Bouros Interferons and Their Application in the Diseases of the Lung Chest, January 1, 2003; 123(1): 209 - 216. [Abstract] [Full Text] [PDF]

				O. Olakanmi, L. S. Schlesinger, A. Ahmed, and B. E. Britigan Intraphagosomal Mycobacterium tuberculosis Acquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools. IMPACT OF INTERFERON-gamma AND HEMOCHROMATOSIS J. Biol. Chem., December 13, 2002; 277(51): 49727 - 49734. [Abstract] [Full Text] [PDF]

				C. E. Gerber, G. Bruchelt, U. B. Falk, A. Kimpfler, O. Hauschild, S. Kuci, T. Bachi, D. Niethammer, and R. Schubert Reconstitution of bactericidal activity in chronic granulomatous disease cells by glucose-oxidase-containing liposomes Blood, November 15, 2001; 98(10): 3097 - 3105. [Abstract] [Full Text] [PDF]

				J. C. Deng, K. Tateda, X. Zeng, and T. J. Standiford Transient Transgenic Expression of Gamma Interferon Promotes Legionella pneumophila Clearance in Immunocompetent Hosts Infect. Immun., October 1, 2001; 69(10): 6382 - 6390. [Abstract] [Full Text] [PDF]

				F. Dutly and M. Altwegg Whipple's Disease and ""Tropheryma whippelii"" Clin. Microbiol. Rev., July 1, 2001; 14(3): 561 - 583. [Abstract] [Full Text] [PDF]

				J. A. Lekstrom-Himes and J. I. Gallin Immunodeficiency Diseases Caused by Defects in Phagocytes N. Engl. J. Med., December 7, 2000; 343(23): 1703 - 1714. [Full Text] [PDF]

				S A Misbah and N P Mapstone Whipple's disease revisited J. Clin. Pathol., October 1, 2000; 53(10): 750 - 755. [Abstract] [Full Text] [PDF]

				Y. Zhang, G. Pilon, A. Marette, and V. E. Baracos Cytokines and endotoxin induce cytokine receptors in skeletal muscle Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E196 - E205. [Abstract] [Full Text] [PDF]

				E. U. Bagriacik and J. R. Klein The Thyrotropin (Thyroid-Stimulating Hormone) Receptor Is Expressed on Murine Dendritic Cells and on a Subset of CD45RBhigh Lymph Node T Cells: Functional Role for Thyroid-Stimulating Hormone During Immune Activation J. Immunol., June 15, 2000; 164(12): 6158 - 6165. [Abstract] [Full Text] [PDF]

				B. H. Segal, N. Sakamoto, M. Patel, K. Maemura, A. S. Klein, S. M. Holland, and G. B. Bulkley Xanthine Oxidase Contributes to Host Defense against Burkholderia cepacia in the p47phox-/- Mouse Model of Chronic Granulomatous Disease Infect. Immun., April 1, 2000; 68(4): 2374 - 2378. [Abstract] [Full Text] [PDF]

				B. MEMOLI, L. MARZANO, V. BISESTI, M. ANDREUCCI, and B. GUIDA Hemodialysis-Related Lymphomononuclear Release of Interleukin-12 in Patients with End-Stage Renal Disease J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2171 - 2176. [Abstract] [Full Text]

				D. Nandan, R. Lo, and N. E. Reiner Activation of Phosphotyrosine Phosphatase Activity Attenuates Mitogen-Activated Protein Kinase Signaling and Inhibits c-FOS and Nitric Oxide Synthase Expression in Macrophages Infected with Leishmania donovani Infect. Immun., August 1, 1999; 67(8): 4055 - 4063. [Abstract] [Full Text] [PDF]

				D. A. Schwartz, C. L. Wohlford-Lenane, T. J. Quinn, and A. M. Krieg Bacterial DNA or Oligonucleotides Containing Unmethylated CpG Motifs Can Minimize Lipopolysaccharide-Induced Inflammation in the Lower Respiratory Tract Through an IL-12-Dependent Pathway J. Immunol., July 1, 1999; 163(1): 224 - 231. [Abstract] [Full Text] [PDF]

				B. H. Segal, T. M. Doherty, T. A. Wynn, A. W. Cheever, A. Sher, and S. M. Holland The p47phox-/- Mouse Model of Chronic Granulomatous Disease Has Normal Granuloma Formation and Cytokine Responses to Mycobacterium avium and Schistosoma mansoni Eggs Infect. Immun., April 1, 1999; 67(4): 1659 - 1665. [Abstract] [Full Text] [PDF]

				A. S. Colsky, A. Hanly, G. Elgart, and F. A. Kerdel Treatment of Refractory Disseminated Mycobacterium abscessus Infection With Interferon Gamma Therapy Arch Dermatol, February 1, 1999; 135(2): 125 - 127. [Full Text] [PDF]