 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 December 1995 | Volume 123 Issue 11 | Pages 845-847
Objective: To compare the prevalence of genital herpes simplex virus type 2 (HSV-2) shedding in human immunodeficiency virus (HIV)-seropositive women and HIV-seronegative women.
Design: Cross-sectional study
Setting: A major inner-city medical center.
Patients: 106 women who were HIV-seropositive and HSV-2-seropositive and 70 women who were HIV-seronegative and HSV-2-seropositive were enrolled from various primary care settings.
Measurements: Herpes simplex virus type 2 antibody determinations were done for all patients. Regardless of symptoms, vulvar and cervical HSV cultures were obtained from all HIV-seropositive women and from a randomly selected subgroup of HIV-seronegative women.
Results: The prevalence of HSV-2 shedding was nearly four times greater in HIV-seropositive than in HIV-seronegative women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% CI, 1.0 to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine percent of viral shedding among HIV-seropositive women was asymptomatic. Overall viral shedding increased significantly as the CD4 cell count decreased.
Conclusions: Women with HIV infection, particularly those with low CD4 cell counts, shed HSV-2 from the vulva and cervix more commonly than women not infected with HIV. Most of this shedding is asymptomatic.
Author and Article Information
From the State University of New York-Health Science Center at Brooklyn, Brooklyn, New York; and the Johns Hopkins University School of Medicine, Baltimore, Maryland.
BRIEF COMMUNICATION
Increased Genital Shedding of Herpes Simplex Virus Type 2 in HIV-Seropositive Women
Grant Support: In part by NIH AI31834-03, CDC/CONRAD CSA-92-100, and NIAID NO1-AI-95014.
Requests for Reprints: Michael H. Augenbraun, MD, Box 56 SUNYHSCB, 450 Clarkson Avenue, Brooklyn, NY 11203.
Current Author Addresses: Dr. Augenbraun, Box 56 SUNY-HSCB, 450 Clarkson Avenue, Brooklyn, NY 11203.
This article has been cited by other articles:
|
|
 |
|
  A. Svensson, A.-M. H. Bergin, G.-B. Lowhagen, P. Tunback, L. Bellner, L. Padyukov, and K. Eriksson A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in humans J. Gen. Virol., September 1, 2008; 89(9): 2262 - 2268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, N. Wang, R. Y Chen, G. B Sharp, Y. Ma, G. Wang, G. Ding, and Z. Wu Prevalence and predictors of herpes simplex virus type 2 infection among female sex workers in Yunnan Province, China Int J STD AIDS, September 1, 2008; 19(9): 635 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Temoshok and R. L. Wald Integrating Multidimensional HIV Prevention Programs Into Healthcare Settings Psychosom Med, June 1, 2008; 70(5): 612 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bettahi, A. B. Nesburn, S. Yoon, X. Zhang, A. Mohebbi, V. Sue, A. Vanderberg, S. L. Wechsler, and L. BenMohamed Protective Immunity against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4643 - 4653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhu, D. M. Koelle, J. Cao, J. Vazquez, M. L. Huang, F. Hladik, A. Wald, and L. Corey Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation J. Exp. Med., March 19, 2007; 204(3): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Legoff, H. Bouhlal, G. Gresenguet, H. Weiss, N. Khonde, H. Hocini, N. Desire, A. Si-Mohamed, J. de Dieu Longo, C. Chemin, et al. Real-Time PCR Quantification of Genital Shedding of Herpes Simplex Virus (HSV) and Human Immunodeficiency Virus (HIV) in Women Coinfected with HSV and HIV J. Clin. Microbiol., February 1, 2006; 44(2): 423 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L F Johnson, D J Coetzee, and R E Dorrington Sentinel surveillance of sexually transmitted infections in South Africa: a review Sex. Transm. Inf., August 1, 2005; 81(4): 287 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Eriksson, L. Bellner, S. Gorander, G.-B. Lowhagen, P. Tunback, K. Rydberg, and J.-A. Liljeqvist CD4+ T-cell responses to herpes simplex virus type 2 (HSV-2) glycoprotein G are type specific and differ in symptomatic and asymptomatic HSV-2-infected individuals J. Gen. Virol., August 1, 2004; 85(8): 2139 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Lai, C Y Chen, S A Morse, Y. Htun, H G Fehler, H Liu, and R C Ballard Increasing relative prevalence of HSV-2 infection among men with genital ulcers from a mining community in South Africa Sex. Transm. Inf., June 1, 2003; 79(3): 202 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Huff, R. Eberle, J. Capitanio, S. S. Zhou, and P. A. Barry Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques J. Gen. Virol., January 1, 2003; 84(1): 83 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E L Korenromp, R Bakker, R Gray, M J Wawer, D Serwadda, and J D F Habbema The effect of HIV, behavioural change, and STD syndromic management on STD epidemiology in sub-Saharan Africa: simulations of Uganda Sex. Transm. Inf., April 1, 2002; 78(90001): i55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B H B van Benthem, J Spaargaren, J A R van den Hoek, J Merks, R A Coutinho, and M Prins Prevalence and risk factors of HSV-1 and HSV-2 antibodies in European HIV infected women Sex. Transm. Inf., April 1, 2001; 77(2): 120 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Severson and S. K. Tyring Relation Between Herpes Simplex Viruses and Human Immunodeficiency Virus Infections Arch Dermatol, November 1, 1999; 135(11): 1393 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schacker, A. J. Ryncarz, J. Goddard, K. Diem, M. Shaughnessy, and L. Corey Frequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1-Infected Men JAMA, July 1, 1998; 280(1): 61 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Posavad, D. M. Koelle, M. F. Shaughnessy, and L. Corey Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses PNAS, September 16, 1997; 94(19): 10289 - 10294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Genital Shedding of HSV-2 AIDS Clinical Care, February 1, 1996; 1996(201): 9 - 9. [Full Text]
|
|
Article
