 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
15 May 1995 | Volume 122 Issue 10 | Pages 767-769
Objective: To determine the effect of eradicating Helicobacter pylori infection on the course of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
Design: Prospective cohort study.
Setting: University internal medicine clinics, a referral oncology center in southern Switzerland, and a gastroenterology referral center in northern Italy.
Patients: 26 patients with localized primary low-grade gastric MALT lymphoma.
Intervention: Treatment for H. pylori infection (bismuth or omeprazole or both, amoxicillin, and metronidazole for 14 days).
Main Outcome Measures: Endoscopic biopsy specimens of the gastric mucosa were obtained every 3 to 6 months after treatment for H. pylori infection.
Results: Helicobacter pylori was completely eradicated in 25 of 26 patients, but 4 patients needed second-line antibiotic treatment to eradicate the microorganism. Disappearance or almost total regression of the lymphomatous tissue was observed in 15 of the 25 evaluable patients (60%; CI, 39% to 79%); however, disappearance or almost total regression was evident in the first biopsy specimen after treatment for H. pylori infection in only 8 of the 15 patients.
Conclusions: Our study confirms recent anecdotal reports of regression of gastric MALT lymphoma after eradication of H. pylori and indicates that the growth of these extranodal lymphomas may depend on H. pylori.
Author and Article Information
From Ospedale San Giovanni, Bellinzona, Switzerland. Ospedale Multizonale, Varese, Italy. Ospedale S'Orsola-FBF, Brescia, Italy. Istituto Cantonale di Patologia, Locarno, Switzerland.
BRIEF COMMUNICATION
Eradication of Helicobacter pylori Infection in Primary Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue
Requests for Reprints: Professor Franco Cavalli, MD, Servizio Oncologico, Ospedale San Giovanni, 6500 Bellinzona, Switzerland.
This article has been cited by other articles:
|
|
 |
|
  W Fischbach, M E Goebeler, A Ruskone-Fourmestraux, T Wundisch, A Neubauer, M Raderer, A Savio, and for the EGILS (European Gastro-Intestinal Lymphoma Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series Gut, December 1, 2007; 56(12): 1685 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Cohen, M. Petryk, M. Varma, P. S. Kozuch, E. D. Ames, and M. L. Grossbard Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue Oncologist, November 1, 2006; 11(10): 1100 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation Blood, April 15, 2006; 107(8): 3034 - 3044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-T. Chen, J.-T. Lin, J. J. Tai, G.-H. Chen, H.-Z. Yeh, S.-S. Yang, H.-P. Wang, S.-H. Kuo, B.-S. Sheu, C.-M. Jan, et al. Long-Term Results of Anti-Helicobacter pylori Therapy in Early-Stage Gastric High-Grade Transformed MALT Lymphoma J Natl Cancer Inst, September 21, 2005; 97(18): 1345 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mueller, J. O'Rourke, P. Chu, A. Chu, M. F. Dixon, D. M. Bouley, A. Lee, and S. Falkow The Role of Antigenic Drive and Tumor-Infiltrating Accessory Cells in the Pathogenesis of Helicobacter-Induced Mucosa-Associated Lymphoid Tissue Lymphoma Am. J. Pathol., September 1, 2005; 167(3): 797 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Montalban, A. Santon, C. Redondo, M. Garcia-Cosio, D. Boixeda, E. Vazquez-Sequeiros, F. Norman, C. M. de Argila, I. Alvarez, V. Abraira, et al. Long-term persistence of molecular disease after histological remission in low-grade gastric MALT lymphoma treated with H. pylori eradication. Lack of association with translocation t(11;18): a 10-year updated follow-up of a prospective study Ann. Onc., September 1, 2005; 16(9): 1539 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Levy, C. Copie-Bergman, C. Gameiro, M.-T. Chaumette, M.-H. Delfau-Larue, C. Haioun, A. Charachon, F. Hemery, P. Gaulard, K. Leroy, et al. Prognostic Value of Translocation t(11;18) in Tumoral Response of Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue Type to Oral Chemotherapy J. Clin. Oncol., August 1, 2005; 23(22): 5061 - 5066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S P Misra, V Misra, and M Dwivedi Low grade B cell gastric mucosa associated lymphoma presenting as upper gastrointestinal bleeding from non-healing stomal ulcers Postgrad. Med. J., February 1, 2005; 81(952): 135 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Alpen, R. Kuse, R. Parwaresch, H. K. Muller-Hermelink, M. Stolte, and A. Neubauer Ongoing Monoclonal B-Cell Proliferation Is Not Common in Gastric B-Cell Lymphoma After Combined Radiochemotherapy J. Clin. Oncol., August 1, 2004; 22(15): 3039 - 3045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Fischbach, M-E Goebeler-Kolve, B Dragosics, A Greiner, and M Stolte Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series Gut, January 1, 2004; 53(1): 34 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Tsang, M. K. Gospodarowicz, M. Pintilie, W. Wells, D. C. Hodgson, A. Sun, M. Crump, and B. J. Patterson Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome J. Clin. Oncol., November 15, 2003; 21(22): 4157 - 4164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Aljurf, T. W. Owaidah, A. Ezzat, E. Ibrahim, and A. Tbakhi Antigen- and/or immune-driven lymphoproliferative disorders Ann. Onc., November 1, 2003; 14(11): 1595 - 1606. [Full Text] [PDF]
|
|
|
|
|
|
A Puspok, M Raderer, A Chott, B Dragosics, A Gangl, and R Schofl Endoscopic ultrasound in the follow up and response assessment of patients with primary gastric lymphoma Gut, November 1, 2002; 51(5): 691 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-S. Park, K. W. Kim, J.-S. Yu, C. Park, J. K. Kim, S.-W. Yoon, K.-H. Lee, Y. H. Ryu, H. Kim, M.-J. Kim, et al. Radiographic Findings of Primary B-Cell Lymphoma of the Stomach: Low-Grade Versus High-Grade Malignancy in Relation to the Mucosa-Associated Lymphoid Tissue Concept Am. J. Roentgenol., November 1, 2002; 179(5): 1297 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Stolte, E Bayerdorffer, A Morgner, B Alpen, T Wundisch, C Thiede, and A Neubauer Helicobacter and gastric MALT lymphoma Gut, May 1, 2002; 50(90003): iii19 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J G Fox The non-H pylori helicobacters: their expanding role in gastrointestinal and systemic diseases Gut, February 1, 2002; 50(2): 273 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-T. Chen, J.-T. Lin, R.-Y. Shyu, C.-M. Jan, C.-L. Chen, I-P. Chiang, S.-M. Liu, I.-J. Su, and A.-L. Cheng Prospective Study of Helicobacter pylori Eradication Therapy in Stage IE High-Grade Mucosa-Associated Lymphoid Tissue Lymphoma of the Stomach J. Clin. Oncol., November 15, 2001; 19(22): 4245 - 4251. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. S. Levine Invited Commentary RadioGraphics, November 1, 2001; 21(6): 1502 - 1504. [Full Text] [PDF]
|
|
|
|
|
|
R. Marasca, P. Vaccari, M. Luppi, P. Zucchini, I. Castelli, P. Barozzi, A. Cuoghi, and G. Torelli Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma Am. J. Pathol., July 1, 2001; 159(1): 253 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Maggi Solca, M. V. Bernasconi, C. Valsangiacomo, L.-J. Van Doorn, and J.-C. Piffaretti Population genetics of Helicobacter pylori in the southern part of Switzerland analysed by sequencing of four housekeeping genes (atpD, glnA, scoB and recA), and by vacA, cagA, iceA and IS605 genotyping Microbiology, June 1, 2001; 147(6): 1693 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Morgner, S. Miehlke, W. Fischbach, W. Schmitt, H. Muller-Hermelink, A. Greiner, C. Thiede, J. Schetelig, A. Neubauer, M. Stolte, et al. Complete Remission of Primary High-Grade B-Cell Gastric Lymphoma After Cure of Helicobacter pylori Infection J. Clin. Oncol., April 1, 2001; 19(7): 2041 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Nakamura, T Matsumoto, H Suekane, M Takeshita, K Hizawa, M Kawasaki, T Yao, M Tsuneyoshi, M Iida, and M Fujishima Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori Gut, April 1, 2001; 48(4): 454 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thiede, T. Wundisch, B. Alpen, B. Neubauer, A. Morgner, M. Schmitz, G. Ehninger, M. Stolte, E. Bayerdorffer, and A. Neubauer Long-Term Persistence of Monoclonal B Cells After Cure of Helicobacter pylori Infection and Complete Histologic Remission in Gastric Mucosa-Associated Lymphoid Tissue B-Cell Lymphoma J. Clin. Oncol., March 15, 2001; 19(6): 1600 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A MORGNER, E BAYERDORFFER, A NEUBAUER, and M STOLTE Helicobacter pylori associated gastric B cell MALT lymphoma: predictive factors for regression Gut, March 1, 2001; 48(3): 290 - 292. [Full Text] [PDF]
|
|
|
|
|
|
C Bariol, A Field, C R Vickers, and R Ward Regression of gastric T cell lymphoma with eradication of Helicobacter pylori Gut, February 1, 2001; 48(2): 269 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Solnick and D. B. Schauer Emergence of Diverse Helicobacter Species in the Pathogenesis of Gastric and Enterohepatic Diseases Clin. Microbiol. Rev., January 1, 2001; 14(1): 59 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cavalli, P. G. Isaacson, R. D. Gascoyne, and E. Zucca MALT Lymphomas Hematology, January 1, 2001; 2001(1): 241 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zucca, F. Bertoni, E. Roggero, and F. Cavalli The gastric marginal zone B-cell lymphoma of MALT type Blood, July 15, 2000; 96(2): 410 - 419. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pinotti, C. Chini, and C. Capella Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after Helicobacter pylori Eradication Ann Intern Med, May 16, 2000; 132(10): 846 - 846. [Full Text] [PDF]
|
|
|
|
 |
|
 W. L. Peterson, A. M. Fendrick, D. R. Cave, D. A. Peura, S. M. Garabedian-Ruffalo, and L. Laine Helicobacter pylori-Related Disease: Guidelines for Testing and Treatment Arch Intern Med, May 8, 2000; 160(9): 1285 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshino, K. Omonishi, K. Kobayashi, T. Mannami, H. Okada, M. Mizuno, I. Yamadori, E. Kondo, and T. Akagi Clinicopathological features of gastric mucosa associated lymphoid tissue (MALT) lymphomas: high grade transformation and comparison with diffuse large B cell lymphomas without MALT lymphoma features J. Clin. Pathol., March 1, 2000; 53(3): 187 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Raderer, F Pfeffel, G Pohl, C Mannhalter, J Valencak, and A Chott Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori Gut, January 1, 2000; 46(1): 133 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Steinbach, R. Ford, G. Glober, D. Sample, F. B. Hagemeister, P. M. Lynch, P. W. McLaughlin, M. A. Rodriguez, J. E. Romaguera, A. H. Sarris, et al. Antibiotic Treatment of Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue: An Uncontrolled Trial Ann Intern Med, July 20, 1999; 131(2): 88 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Taupin, A. Occhialini, A. Ruskone-Fourmestraux, J.-C. Delchier, J.-C. Rambaud, and F. Megraud Serum Antibody Responses to Helicobacter pylori and the cagA Marker in Patients with Mucosa-Associated Lymphoid Tissue Lymphoma Clin. Vaccine Immunol., July 1, 1999; 6(4): 633 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zucca, F. Bertoni, E. Roggero, G. Bosshard, G. Cazzaniga, E. Pedrinis, A. Biondi, and F. Cavalli Molecular Analysis of the Progression from Helicobacter pylori-Associated Chronic Gastritis to Mucosa-Associated Lymphoid-Tissue Lymphoma of the Stomach N. Engl. J. Med., March 19, 1998; 338(12): 804 - 810. [Full Text] [PDF]
|
|
|
|
|
|
The Non-Hodgkin's Lymphoma Classification Project A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood, June 1, 1997; 89(11): 3909 - 3918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fischbach, R. Engemann, and M. Stolte A Pitfall in Assessing Gastric Lymphoma after Eradication of Helicobacter pylori N. Engl. J. Med., May 22, 1997; 336(21): 1529 - 1530. [Full Text]
|
|
|
|
|
|
L. M. Kaplan and F. M. Graeme-Cook Case 9-1997- A 39-Year-Old Woman with Pernicious Anemia and a Gastric Mass N. Engl. J. Med., March 20, 1997; 336(12): 861 - 867. [Full Text] [PDF]
|
|
Article
