Annals
Established in 1927 by the American College of Physicians
:
Advanced search
 
box Article
 arrow  Table of Contents                
space
 arrow  Full Text of this article Free
space
box Services
 arrow  Send comment/rapid response letter
space
 arrow  Notify a friend about this article
space
 arrow  Alert me when this article is cited
space
 arrow  Add to Personal Archive
space
 arrow  Download to Citation Manager
space
 arrow  ACP Search                        
space
 arrow  Get Permissions
space
box Google Scholar
 arrow  Search for Related Content
space
box PubMed
Articles in PubMed by Author:
  arrow  Pi-Sunyer, F. X.
space
 arrow  Related Articles in PubMed
space
 arrow  PubMed Citation
space
 arrow  PubMed
space

METHODS FOR VOLUNTARY WEIGHT LOSS AND CONTROL: NATIONAL INSTITUTES OF HEALTH TECHNOLOGY ASSESSMENT CONFERENCE

Medical Hazards of Obesity

right arrow F. Xavier Pi-Sunyer

1 October 1993 | Volume 119 Issue 7 Part 2 | Pages 655-660

The medical hazards of obesity are discussed. Risks include insulin resistance, diabetes mellitus, hypertriglyceridemia, decreased levels of high-density lipoprotein cholesterol, and increased levels of low-density lipoprotein cholesterol. Obesity is also associated with gallbladder disease and some forms of cancer as well as sleep apnea, chronic hypoxia and hypercapnia, and degenerative joint disease. Obesity is an independent risk factor for death from coronary heart disease. A central distribution of body fat enhances the risk for most of these conditions.

Author and Article Information
space

From St. Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York.
Requests for Reprints: F. Xavier Pi-Sunyer, MD, Obesity Research Center, St. Luke's-Roosevelt Hospital Center, New York, NY 10025.
Grant Support: In part by grants P30-DK26687, DK40414, and R55-DK35911 from the National Institutes of Health.




This article has been cited by other articles:


Home page
Asia Pac J Public HealthHome page
Xiaohui Hou
Urban--Rural Disparity of Overweight, Hypertension, Undiagnosed Hypertension, and Untreated Hypertension in China
Asia Pac J Public Health, April 1, 2008; 20(2): 159 - 169.
[Abstract] [PDF]


Home page
CirculationHome page
H. C. McGill Jr, C. A. McMahan, and S. S. Gidding
Preventing Heart Disease in the 21st Century: Implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study
Circulation, March 4, 2008; 117(9): 1216 - 1227.
[Full Text] [PDF]


Home page
AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
C. E. O'Neil and T. A. Nicklas
State of the Art Reviews: Relationship Between Diet/ Physical Activity and Health
American Journal of Lifestyle Medicine, December 1, 2007; 1(6): 457 - 481.
[Abstract] [PDF]


Home page
J Law Med EthicsHome page
P. K. Newby
Are Dietary Intakes and Eating Behaviors Related to Childhood Obesity? A Comprehensive Review of the Evidence
J. Law Med. Ethics, March 1, 2007; 35(1): 35 - 60.
[PDF]


Home page
Am J Health Syst PharmHome page
P. N. Patel and R. Pathak
Rimonabant: A novel selective cannabinoid-1 receptor antagonist for treatment of obesity
Am. J. Health Syst. Pharm., March 1, 2007; 64(5): 481 - 489.
[Abstract] [Full Text] [PDF]


Home page
Ann. Surg. Oncol.Home page
T. Tsujinaka, M. Sasako, S. Yamamoto, T. Sano, Y. Kurokawa, A. Nashimoto, A. Kurita, H. Katai, T. Shimizu, H. Furukawa, et al.
Influence of Overweight on Surgical Complications for Gastric Cancer: Results From a Randomized Control Trial Comparing D2 and Extended Para-aortic D3 Lymphadenectomy (JCOG9501)
Ann. Surg. Oncol., February 1, 2007; 14(2): 355 - 361.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. T. Foster and T. J. Bartness
Sympathetic but not sensory denervation stimulates white adipocyte proliferation
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1630 - R1637.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
I. Huybrechts, D. De Bacquer, I. Van Trimpont, G. De Backer, and S. De Henauw
Validity of Parentally Reported Weight and Height for Preschool-Aged Children in Belgium and Its Impact on Classification Into Body Mass Index Categories
Pediatrics, November 1, 2006; 118(5): 2109 - 2118.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Public HealthHome page
T. M. Smoot, P. Xu, P. Hilsenrath, N. C. Kuppersmith, and K. P. Singh
Gastric Bypass Surgery in the United States, 1998-2002
Am J Public Health, July 1, 2006; 96(7): 1187 - 1189.
[Abstract] [Full Text] [PDF]


Home page
PerfusionHome page
R P. Alston, A. Anderson, and K. Sanger
Is body surface area still the best way to determine pump flow rate during cardiopulmonary bypass?
Perfusion, May 1, 2006; 21(3): 139 - 147.
[Abstract] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
C. H. Wigfield, J. D. Lindsey, A. Munoz, P. S. Chopra, N. M. Edwards, and R. B. Love
Is extreme obesity a risk factor for cardiac surgery? An analysis of patients with a BMI>/=40.
Eur. J. Cardiothorac. Surg., April 1, 2006; 29(4): 434 - 440.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
S. M. Grundy
Metabolic Syndrome: Connecting and Reconciling Cardiovascular and Diabetes Worlds
J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1093 - 1100.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
H. M. Farin, F. Abbasi, and G. M Reaven
Body mass index and waist circumference both contribute to differences in insulin-mediated glucose disposal in nondiabetic adults
Am. J. Clinical Nutrition, January 1, 2006; 83(1): 47 - 51.
[Abstract] [Full Text] [PDF]


Home page
Eur J OrthodHome page
A. Sadeghianrizi, C.-M. Forsberg, C. Marcus, and G. Dahllof
Craniofacial development in obese adolescents
Eur J Orthod, December 1, 2005; 27(6): 550 - 555.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
S. M. Grundy, J. I. Cleeman, S. R. Daniels, K. A. Donato, R. H. Eckel, B. A. Franklin, D. J. Gordon, R. M. Krauss, P. J. Savage, S. C. Smith Jr, et al.
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Circulation, October 25, 2005; 112(17): 2735 - 2752.
[Full Text] [PDF]


Home page
HypertensionHome page
F. Thomas, K. Bean, B. Pannier, J.-M. Oppert, L. Guize, and A. Benetos
Cardiovascular Mortality in Overweight Subjects: The Key Role of Associated Risk Factors
Hypertension, October 1, 2005; 46(4): 654 - 659.
[Abstract] [Full Text] [PDF]


Home page
Clin. Chem.Home page
S. M. Grundy
Point: The Metabolic Syndrome Still Lives
Clin. Chem., August 1, 2005; 51(8): 1352 - 1354.
[Full Text] [PDF]


Home page
Clin. DiabetesHome page
The American Diabetes Association, the North American Association for the Study of Ob, and and the American Society for Clinical Nutrition
Weight Management Using Lifestyle Modification in the Prevention and Management of Type 2 Diabetes: Rationale and Strategies
Clin. Diabetes, July 1, 2005; 23(3): 130 - 136.
[Full Text] [PDF]


Home page
JBJSHome page
M. A. Karunakar, S. N. Shah, and S. Jerabek
Body Mass Index as a Predictor of Complications After Operative Treatment of Acetabular Fractures
J. Bone Joint Surg. Am., July 1, 2005; 87(7): 1498 - 1502.
[Abstract] [Full Text] [PDF]


Home page
PediatricsHome page
E. P. Whitlock, S. B. Williams, R. Gold, P. R. Smith, and S. A. Shipman
Screening and Interventions for Childhood Overweight: A Summary of Evidence for the US Preventive Services Task Force
Pediatrics, July 1, 2005; 116(1): e125 - e144.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
D. E. Ray, S. C. Matchett, K. Baker, T. Wasser, and M. J. Young
The Effect of Body Mass Index on Patient Outcomes in a Medical ICU
Chest, June 1, 2005; 127(6): 2125 - 2131.
[Abstract] [Full Text] [PDF]


Home page
Clin. Chem.Home page
G. M. Reaven
The Metabolic Syndrome: Requiescat in Pace
Clin. Chem., June 1, 2005; 51(6): 931 - 938.
[Abstract] [Full Text] [PDF]


Home page
J Intensive Care MedHome page
M. Yaegashi, R. Jean, M. Zuriqat, S. Noack, and P. Homel
Outcome of Morbid Obesity in the Intensive Care Unit
J Intensive Care Med, May 1, 2005; 20(3): 147 - 154.
[Abstract] [PDF]


Home page
Obstet GynecolHome page
P. S. Ramsey, A. M. White, D. A. Guinn, G. C. Lu, S. M. Ramin, J. K. Davies, C. L. Neely, C. Newby, L. Fonseca, A. S. Case, et al.
Subcutaneous Tissue Reapproximation, Alone or in Combination With Drain, in Obese Women Undergoing Cesarean Delivery
Obstet. Gynecol., May 1, 2005; 105(5): 967 - 973.
[Abstract] [Full Text] [PDF]


Home page
ANN INTERN MEDHome page
Z. Li, M. Maglione, W. Tu, W. Mojica, D. Arterburn, L. R. Shugarman, L. Hilton, M. Suttorp, V. Solomon, P. G. Shekelle, et al.
Meta-Analysis: Pharmacologic Treatment of Obesity
Ann Intern Med, April 5, 2005; 142(7): 532 - 546.
[Abstract] [Full Text] [PDF]


Home page
Hum Exp ToxicolHome page
E.-J. Kim, E.-K. Park, and K.-H. Suh
Safety pharmacology of sibutramine mesylate, an anti-obesity drug
Human and Experimental Toxicology, March 1, 2005; 24(3): 109 - 119.
[Abstract] [PDF]


Home page
Eur Heart JHome page
F. Gustafsson, C. B. Kragelund, C. Torp-Pedersen, M. Seibaek, H. Burchardt, D. Akkan, J. J. Thune, L. Kober, and for the DIAMOND study group
Effect of obesity and being overweight on long-term mortality in congestive heart failure: influence of left ventricular systolic function
Eur. Heart J., January 1, 2005; 26(1): 58 - 64.
[Abstract] [Full Text] [PDF]


Home page
Arch Gen PsychiatryHome page
D. C. Henderson, E. Cagliero, P. M. Copeland, C. P. Borba, E. Evins, D. Hayden, M. T. Weber, E. J. Anderson, D. B. Allison, T. B. Daley, et al.
Glucose Metabolism in Patients With Schizophrenia Treated With Atypical Antipsychotic Agents: A Frequently Sampled Intravenous Glucose Tolerance Test and Minimal Model Analysis
Arch Gen Psychiatry, January 1, 2005; 62(1): 19 - 28.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
M. A. Raebel, D. C. Malone, D. A. Conner, S. Xu, J. A. Porter, and F. A. Lanty
Health Services Use and Health Care Costs of Obese and Nonobese Individuals
Arch Intern Med, October 25, 2004; 164(19): 2135 - 2140.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Public HealthHome page
W. H. Oddy, J. L. Sherriff, N. H. de Klerk, G. E. Kendall, P. D. Sly, L. J. Beilin, K. B. Blake, L. I. Landau, and F. J. Stanley
The Relation of Breastfeeding and Body Mass Index to Asthma and Atopy in Children: A Prospective Cohort Study to Age 6 Years
Am J Public Health, September 1, 2004; 94(9): 1531 - 1537.
[Abstract] [Full Text] [PDF]


Home page
Arch SurgHome page
A. L. Neville, C. V. R. Brown, J. Weng, D. Demetriades, and G. C. Velmahos
Obesity Is an Independent Risk Factor of Mortality in Severely Injured Blunt Trauma Patients
Arch Surg, September 1, 2004; 139(9): 983 - 987.
[Abstract] [Full Text] [PDF]


Home page
Arch. Dis. Child.Home page
E Stenhouse, D E Wright, A T Hattersley, and B A Millward
Weight differences in Plymouth toddlers compared to the British Growth Reference Population
Arch. Dis. Child., September 1, 2004; 89(9): 843 - 844.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
S. Klein, N. F Sheard, X. Pi-Sunyer, A. Daly, J. Wylie-Rosett, K. Kulkarni, and N. G Clark
Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition
Am. J. Clinical Nutrition, August 1, 2004; 80(2): 257 - 263.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
S. Klein, N. F. Sheard, X. Pi-Sunyer, A. Daly, J. Wylie-Rosett, K. Kulkarni, and N. G. Clark
Weight Management Through Lifestyle Modification for the Prevention and Management of Type 2 Diabetes: Rationale and Strategies: A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition
Diabetes Care, August 1, 2004; 27(8): 2067 - 2073.
[Full Text] [PDF]


Home page
Arch Intern MedHome page
S. L. Norris, X. Zhang, A. Avenell, E. Gregg, C. H. Schmid, C. Kim, and J. Lau
Efficacy of Pharmacotherapy for Weight Loss in Adults With Type 2 Diabetes Mellitus: A Meta-analysis
Arch Intern Med, July 12, 2004; 164(13): 1395 - 1404.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
D. E. Kelley, L. H. Kuller, T. M. McKolanis, P. Harper, J. Mancino, and S. Kalhan
Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes
Diabetes Care, January 1, 2004; 27(1): 33 - 40.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
K. A. Takahashi, J. L. Smart, H. Liu, and R. D. Cone
The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is a Nonspecific Neuronal Activator
Endocrinology, January 1, 2004; 145(1): 184 - 193.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
C. U. Onyike, R. M. Crum, H. B. Lee, C. G. Lyketsos, and W. W. Eaton
Is Obesity Associated with Major Depression? Results from the Third National Health and Nutrition Examination Survey
Am. J. Epidemiol., December 15, 2003; 158(12): 1139 - 1147.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Public HealthHome page
J. S. Haas, L. B. Lee, C. P. Kaplan, D. Sonneborn, K. A. Phillips, and S.-Y. Liang
The Association of Race, Socioeconomic Status, and Health Insurance Status With the Prevalence of Overweight Among Children and Adolescents
Am J Public Health, December 1, 2003; 93(12): 2105 - 2110.
[Abstract] [Full Text] [PDF]


Home page
ANN INTERN MEDHome page
T. McLaughlin, F. Abbasi, K. Cheal, J. Chu, C. Lamendola, and G. Reaven
Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant
Ann Intern Med, November 18, 2003; 139(10): 802 - 809.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
J. H. O. van Tilburg, L. A. Sandkuijl, E. Strengman, H. van Someren, C. A. E. Rigters-Aris, P. L. Pearson, T. W van Haeften, and C. Wijmenga
A Genome-Wide Scan in Type 2 Diabetes Mellitus Provides Independent Replication of a Susceptibility Locus on 18p11 and Suggests the Existence of Novel Loci on 2q12 and 19q13
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2223 - 2230.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
M. E.J. Lean and F.-G. Pajonk
Patients on Atypical Antipsychotic Drugs: Another high-risk group for type 2 diabetes
Diabetes Care, May 1, 2003; 26(5): 1597 - 1605.
[Abstract] [Full Text] [PDF]


Home page
Arch SurgHome page
E. H. Livingston and A. S. Fink
Quality of Life: Cost and Future of Bariatric Surgery
Arch Surg, April 1, 2003; 138(4): 383 - 388.
[Full Text] [PDF]


Home page
ANN INTERN MEDHome page
E. W. Gregg, R. B. Gerzoff, T. J. Thompson, and D. F. Williamson
Intentional Weight Loss and Death in Overweight and Obese U.S. Adults 35 Years of Age and Older
Ann Intern Med, March 4, 2003; 138(5): 383 - 389.
[Abstract] [Full Text] [PDF]


Home page
ANN INTERN MEDHome page
G. M. Reaven
Importance of Identifying the Overweight Patient Who Will Benefit the Most by Losing Weight
Ann Intern Med, March 4, 2003; 138(5): 420 - 423.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
X. Pi-Sunyer
A Clinical View of the Obesity Problem
Science, February 7, 2003; 299(5608): 859 - 860.
[Abstract] [Full Text] [PDF]


Home page
Am. J. PsychiatryHome page
M. C.M. Ryan, P. Collins, and J. H. Thakore
Impaired Fasting Glucose Tolerance in First-Episode, Drug-Naive Patients With Schizophrenia
Am J Psychiatry, February 1, 2003; 160(2): 284 - 289.
[Abstract] [Full Text] [PDF]


Home page
J Child NeurolHome page
V. Biton, P. Levisohn, S. Hoyler, A. Vuong, and A. E. Hammer
Lamotrigine Versus Valproate Monotherapy--Associated Weight Change in Adolescents With Epilepsy: Results From a Post Hoc Analysis of a Randomized, Double-Blind Clinical Trial
J Child Neurol, February 1, 2003; 18(2): 133 - 139.
[Abstract] [PDF]


Home page
DiabetesHome page
R. L. Hull, S. Andrikopoulos, C. B. Verchere, J. Vidal, F. Wang, M. Cnop, R. L. Prigeon, and S. E. Kahn
Increased Dietary Fat Promotes Islet Amyloid Formation and {beta}-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid
Diabetes, February 1, 2003; 52(2): 372 - 379.
[Abstract] [Full Text] [PDF]


Home page
J Am Board Fam MedHome page
C. A. Lemay, S. Cashman, J. Savageau, K. Fletcher, R. Kinney, and E. Long-Middleton
Underdiagnosis of Obesity at a Community Health Center
J Am Board Fam Med, January 1, 2003; 16(1): 14 - 21.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
S. Dai, D. R. Labarthe, J. A. Grunbaum, R. B. Harrist, and W. H. Mueller
Longitudinal Analysis of Changes in Indices of Obesity from Age 8 Years to Age 18 Years: Project HeartBeat!
Am. J. Epidemiol., October 15, 2002; 156(8): 720 - 729.
[Abstract] [Full Text] [PDF]


Home page
Drug Metab. Dispos.Home page
R. A. Stearns, R. R. Miller, W. Tang, G. Y. Kwei, F. S. Tang, R. J. Mathvink, E. M. Naylor, D. Chitty, V. J. Colandrea, A. E. Weber, et al.
The Pharmacokinetics of a Thiazole Benzenesulfonamide beta 3-Adrenergic Receptor Agonist and Its Analogs in Rats, Dogs, and Monkeys: Improving Oral Bioavailability
Drug Metab. Dispos., July 1, 2002; 30(7): 771 - 777.
[Abstract] [Full Text] [PDF]


Home page
Indoor and Built EnvironmentHome page
J. H. Lange
Has the Indoor and Built Environment Started Changing Modern Health?
Indoor and Built Environment, May 1, 2002; 11(3): 119 - 122.
[PDF]


Home page
J Aging HealthHome page
T. M. Damush, T. E. Stump, and D. O. Clark
Body-Mass Index and 4-Year Change in Health-Related Quality of Life
J Aging Health, May 1, 2002; 14(2): 195 - 210.
[Abstract] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
A. SHTAUVERE-BRAMEUS, W. HAGOPIAN, I. RUMBA, and C. B. SANJEEVI
Antibodies to New Beta Cell Antigen ICA12 in Latvian Diabetes Patients
Ann. N.Y. Acad. Sci., April 1, 2002; 958(1): 297 - 304.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
N. M. PUNJABI, J. D. SORKIN, L. I. KATZEL, A. P. GOLDBERG, A. R. SCHWARTZ, and P. L. SMITH
Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men
Am. J. Respir. Crit. Care Med., March 1, 2002; 165(5): 677 - 682.
[Abstract] [Full Text] [PDF]


Home page
Health Aff (Millwood)Home page
R. Sturm
The Effects Of Obesity, Smoking, And Drinking On Medical Problems And Costs
Health Aff., March 1, 2002; 21(2): 245 - 253.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
A. Colin Bell, L. S. Adair, and B. M. Popkin
Ethnic Differences in the Association between Body Mass Index and Hypertension
Am. J. Epidemiol., February 15, 2002; 155(4): 346 - 353.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
Y. Chen, R. Dales, M. Tang, and D. Krewski
Obesity May Increase the Incidence of Asthma in Women but Not in Men: Longitudinal Observations from the Canadian National Population Health Surveys
Am. J. Epidemiol., February 1, 2002; 155(3): 191 - 197.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
S. C. Redd and A. H. Mokdad
Invited Commentary: Obesity and Asthma--New Perspectives, Research Needs, and Implications for Control Programs
Am. J. Epidemiol., February 1, 2002; 155(3): 198 - 200.
[Full Text] [PDF]


Home page
ChestHome page
A. El-Solh, P. Sikka, E. Bozkanat, W. Jaafar, and J. Davies
Morbid Obesity in the Medical ICU
Chest, December 1, 2001; 120(6): 1989 - 1997.
[Abstract] [Full Text] [PDF]