 |
 |
|
|
|  PubMed
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
15 June 1993 | Volume 118 Issue 12 | Pages 929-936
Objective: To describe the clinical and serologic features of women with silicone breast implants who were referred for symptoms of rheumatic disease.
Design: A case series.
Setting: University and private rheumatology practices.
Patients: A total of 156 women with silicone breast implants and rheumatic disease complaints. Controls for the serologic studies included women with silicone implants and no rheumatic symptoms (n = 12) and women with fibromyalgia without silicone implants (n = 174).
Measurements: Complete physical examination and testing for immunoglobulins; complement; C-reactive protein; rheumatoid factor; and autoantibodies by indirect immunofluorescence, immunodiffusion, and Western blot.
Results: Three subgroups of patients were defined based on clinical and laboratory findings: joint and muscle pain (n = 95), joint swelling (n = 32), and connective tissue disease (n = 29). Most women had normal immunologic studies. The patients with joint swelling had mild, asymmetric, rheumatoid-factor-negative synovitis that did not meet American College of Rheumatology criteria for rheumatoid arthritis. Fourteen patients had a scleroderma-like illness and anti-centromere or anti-PM-Scl antibodies by Western blot. Ten patients had a positive Western blot for BB' polypeptide, a small nuclear ribonucleoprotein (snRNP), but did not meet criteria for systemic lupus erythematosus. No autoantibodies to known disease-related polypeptides were detected on Western blot in the control groups.
Conclusion: Most women with silicone implants and rheumatic complaints had normal results of serologic tests and nonspecific symptoms, suggesting no serious connective tissue disease. However, a subset of women had clinical signs and serologic tests that were unusual even for referred patients. These observations suggest, but cannot establish, that some women with silicone breast implants may develop atypical immunologic reactions.
Author and Article Information
From the University of Missouri-Columbia, the University of South Florida, and the James A. Hailey Veterans Administration Hospital, Tampa, Florida.
ARTICLE
A Clinical and Immunologic Evaluation of Women with Silicone Breast Implants and Symptoms of Rheumatic Disease
Requests for Reprints: Alan J. Bridges, MD, H6/367 Clinical Sciences Center, University of Wisconsin Hospital, 600 Highland Avenue, Madison, WI 53792.
Acknowledgments: The authors thank Frederick W. Miller, MD, PhD, Lori A. Love, MD, PhD, and Dr. Charles L. Puckett, MD, for scientific review. Dr. John Hewitt and Jane Johnson performed the statistical analyses.
Grant Support: In part by grants from the Department of Medicine, University of Missouri-Columbia, and by the St. Petersburg Medical Clinic Foundation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
Related articles in Annals:
This article has been cited by other articles:
|
|
 |
|
  M. Gaubitz, C. Jackisch, W. Domschke, W. Heindel, and B. Pfleiderer Silicone breast implants: correlation between implant ruptures, magnetic resonance spectroscopically estimated silicone presence in the liver, antibody status and clinical symptoms Rheumatology, February 1, 2002; 41(2): 129 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. Cook, J. R. Daling, L. F. Voigt, M. P. deHart, K. E. Malone, J. L. Stanford, N. S. Weiss, L. A. Brinton, M. D. Gammon, and D. Brogan Characteristics of Women With and Without Breast Augmentation JAMA, May 28, 1997; 277(20): 1612 - 1617. [Abstract] [PDF]
|
|
|
|
 |
|
 M. E. Jordan and R. W. M. Blum Should Breast-feeding by Women With Silicone Implants Be Recommended? Arch Pediatr Adolesc Med, August 1, 1996; 150(8): 880 - 881. [Abstract] [PDF]
|
|
|
|
|
|
C. H. Hennekens, I-M. Lee, N. R. Cook, P. R. Hebert, E. W. Karlson, F. LaMotte, J. E. Manson, and J. E. Buring Self-reported Breast Implants and Connective-Tissue Diseases in Female Health Professionals: A Retrospective Cohort Study JAMA, February 28, 1996; 275(8): 616 - 621. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Sanchez-Guerrero, G. A. Colditz, E. W. Karlson, D. J. Hunter, F. E. Speizer, and M. H. Liang Silicone Breast Implants and the Risk of Connective-Tissue Diseases and Symptoms N. Engl. J. Med., June 22, 1995; 332(25): 1666 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Love New Environmental Agents Associated With Lupus-Like Disorders Lupus, December 1, 1994; 3(6): 467 - 471. [Abstract] [PDF]
|
|
|
|
 |
|
 J Sanchez-Guerrero and M H Liang Silicone breast implants and connective tissue diseases BMJ, October 1, 1994; 309(6958): 822 - 823. [Full Text]
|
|
|
|
|
|
S. E. Gabriel, W. M. O'Fallon, L. T. Kurland, C. M. Beard, J. E. Woods, and L. J. Melton Risk of Connective-Tissue Diseases and Other Disorders after Breast Implantation N. Engl. J. Med., June 16, 1994; 330(24): 1697 - 1702. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Levine and N. T. Ilowite Sclerodermalike Esophageal Disease in Children Breast-fed by Mothers With Silicone Breast Implants JAMA, January 19, 1994; 271(3): 213 - 216. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Flick Silicone Implants and Esophageal Dysmotility: Are Breast-fed Infants at Risk? JAMA, January 19, 1994; 271(3): 240 - 241. [Abstract] [PDF]
|
|
|
|
 |
|
 N. Kossovsky and C. J. Freiman Immunology of Silicone Breast Implants J Biomater Appl, January 1, 1994; 8(3): 237 - 246. [Abstract] [PDF]
|
|
|
|
 |
|
 A. J. Bridges and F. B. Vasey Silicone Breast Implants: History, Safety, and Potential Complications Arch Intern Med, December 13, 1993; 153(23): 2638 - 2644. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Kessler, R. B. Merkatz, and R. Schapiro A Call for Higher Standards for Breast Implants JAMA, December 1, 1993; 270(21): 2607 - 2608. [Abstract] [PDF]
|
|
|
|
 |
|
 Silicone Breast Implants and Rheumatic Disease Journal Watch Dermatology, September 1, 1993; 1993(901): 4 - 4. [Full Text]
|
|
