Article    Table of Contents                    Full Text of this article Free    Figures/Tables List  Services    Send comment/rapid response letter    Notify a friend about this article    Alert me when this article is cited    Add to Personal Archive    Download to Citation Manager    ACP Search                            Get Permissions  Google Scholar    Search for Related Content  PubMed Articles in PubMed by Author:    Straus, S. E.    Meier, J.    Related Articles in PubMed    PubMed Citation    PubMed

NIH CONFERENCE

Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management

Stephen E. Straus, MD; Jeffrey I. Cohen, MD; Giovanna Tosato, MD; and Jeffery Meier, MD

1 January 1993 | Volume 118 Issue 1 | Pages 45-58

Epstein-Barr virus (EBV) encodes genes that ensure its persistence in human B lymphocytes. Some of the genes encourage B-cell proliferation; others are poised to evade or defeat immune recognition. Immune restraints on the virus, however, are typically so effective that most infections are never symptomatic. In contrast, acute infectious mononucleosis, a self-limited lymphoproliferative illness, is common in adolescents and young adults. Unbridled proliferative illnesses arise when cellular immunity is grossly defective. Treatment of EBV-associated syndromes is largely supportive. Antiviral drugs have no proven role except in patients with oral hairy leukoplakia. Vaccine development is technically feasible but is not considered a high priority for developed nations.

Author and Article Information

An edited summary of a Clinical Staff Conference held 25 March 1992 at the Amphitheater, Building 10, Bethesda, Maryland. The conference was sponsored by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the Center for Biologics Evaluation and Research, Food and Drug Administration, U.S. Department of Health and Human Services.
Authors who wish to cite a section of the conference and specifically indicate its author may use this example for the form of reference:
Cohen JI. Molecular biology of Epstein-Barr virus and its mechanism of B-cell transformation, pp 48-50. In: Straus SE, moderator. Epstein-Barr virus infections: biology, pathogenesis, and management. Ann Intern Med. 1992; 118: 45-58.
Requests for Reprints: Stephen E. Straus, MD, Medical Virology Section, Laboratory of Clinical Investigation, NIAID, NIH, Building 10, Room 11N228, Bethesda, MD 20892.
Acknowledgments: The authors thank S. E. Pike, K. Jones, K. Taga, P. Frugoni, J. Tanner, M. K. Breinig, J. McKnight, and A. Rosenberg for helping with this work; B. R. Marshall, E. Caruso, and M. Stoughton for providing editorial assistance; and S. Rosen for organizing this conference and providing invaluable advice on the manuscript.

This article has been cited by other articles:

				H Narimatsu, Y Ota, M Kami, K Takeuchi, R Suzuki, K Matsuo, T Matsumura, K Yuji, Y Kishi, T Hamaki, et al. Clinicopathological features of pyothorax-associated lymphoma; a retrospective survey involving 98 patients Ann. Onc., January 1, 2007; 18(1): 122 - 128. [Abstract] [Full Text] [PDF]

				R.A. Marrie Multiple sclerosis and risk-taking QJM, January 1, 2006; 99(1): 63 - 63. [Full Text] [PDF]

				S.S. Lok, Y. Haider, D. Howell, J.P. Stewart, P.S. Hasleton, and J.J. Egan Murine gammaherpes virus as a cofactor in the development of pulmonary fibrosis in bleomycin resistant mice Eur. Respir. J., November 1, 2002; 20(5): 1228 - 1232. [Abstract] [Full Text] [PDF]

				I. Mirza, N. Macpherson, S. Paproski, R. D. Gascoyne, B. Yang, W. G. Finn, and E. D. Hsi Primary Cutaneous Follicular Lymphoma: An Assessment of Clinical, Histopathologic, Immunophenotypic, and Molecular Features J. Clin. Oncol., February 1, 2002; 20(3): 647 - 655. [Abstract] [Full Text] [PDF]

				E. Sharif-Askari, L. M. Fawaz, P. Tran, A. Ahmad, and J. Menezes Interleukin 15-Mediated Induction of Cytotoxic Effector Cells Capable of Eliminating Epstein-Barr Virus-Transformed/Immortalized Lymphocytes in Culture J Natl Cancer Inst, November 21, 2001; 93(22): 1724 - 1732. [Abstract] [Full Text] [PDF]

				Y. Kasahara, A. Yachie, K. Takei, C. Kanegane, K. Okada, K. Ohta, H. Seki, N. Igarashi, K. Maruhashi, K. Katayama, et al. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection Blood, September 15, 2001; 98(6): 1882 - 1888. [Abstract] [Full Text] [PDF]

				J. I. Cohen Epstein-Barr Virus Infection N. Engl. J. Med., August 17, 2000; 343(7): 481 - 492. [Full Text] [PDF]

				L. Quintanilla-Martinez, S. Kumar, F. Fend, E. Reyes, J. Teruya-Feldstein, D. W. Kingma, L. Sorbara, M. Raffeld, S. E. Straus, and E. S. Jaffe Fulminant EBV+ T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome Blood, July 15, 2000; 96(2): 443 - 451. [Abstract] [Full Text] [PDF]

				B.-M. Imbert-Marcille, M. Coste-Burel, N. Robillard, J. Foucaud-Gamen, S. Billaudel, and E. Drouet Sequential Use of Paraformaldehyde and Methanol as Optimal Conditions for the Direct Quantification of ZEBRA and Rta Antigens by Flow Cytometry Clin. Vaccine Immunol., March 1, 2000; 7(2): 206 - 211. [Abstract] [Full Text] [PDF]

				M. Bonnet, J.-M. Guinebretiere, E. Kremmer, V. Grunewald, E. Benhamou, G. Contesso, and I. Joab Detection of Epstein-Barr Virus in Invasive Breast Cancers J Natl Cancer Inst, August 18, 1999; 91(16): 1376 - 1381. [Abstract] [Full Text] [PDF]

				J. Setsuda, J. Teruya-Feldstein, N. L. Harris, J. A. Ferry, L. Sorbara, G. Gupta, E. S. Jaffe, and G. Tosato Interleukin-18, Interferon-{gamma}, IP-10, and Mig Expression in Epstein-Barr Virus-Induced Infectious Mononucleosis and Posttransplant Lymphoproliferative Disease Am. J. Pathol., July 1, 1999; 155(1): 257 - 265. [Abstract] [Full Text] [PDF]

				M. G. Sturgill, R. A. Drachtman, A. G. Ettinger, J. Rubin, and L. J. Ettinger The Influence of Epstein-Barr Virus Seropositivity on the Efficacy of Intravenous Immune Globulin in Children with Immune Thrombocytopenic Purpura Clinical Pediatrics, April 1, 1999; 38(3): 171 - 173. [PDF]

				P. G. Auwaerter Infectious Mononucleosis in Middle Age JAMA, February 3, 1999; 281(5): 454 - 459. [Full Text] [PDF]

				H. Kimura, M. Morita, Y. Yabuta, K. Kuzushima, K. Kato, S. Kojima, T. Matsuyama, and T. Morishima Quantitative Analysis of Epstein-Barr Virus Load by Using a Real-Time PCR Assay J. Clin. Microbiol., January 1, 1999; 37(1): 132 - 136. [Abstract] [Full Text]

				K. E. Nichols, D. P. Harkin, S. Levitz, M. Krainer, K. A. Kolquist, C. Genovese, A. Bernard, M. Ferguson, L. Zuo, E. Snyder, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome PNAS, November 10, 1998; 95(23): 13765 - 13770. [Abstract] [Full Text] [PDF]

				J. Peter and C. G. Ray Infectious Mononucleosis Pediatr. Rev., August 1, 1998; 19(8): 276 - 279. [Full Text] [PDF]

				T. Baldeweg, J. Catalan, and B. G Gazzard Risk of HIV dementia and opportunistic brain disease in AIDS and zidovudine therapy J. Neurol. Neurosurg. Psychiatry, July 1, 1998; 65(1): 34 - 41. [Abstract] [Full Text]

				H. Kanegane, K. Bhatia, M. Gutierrez, H. Kaneda, T. Wada, A. Yachie, H. Seki, T. Arai, S.-i. Kagimoto, M. Okazaki, et al. A Syndrome of Peripheral Blood T-Cell Infection With Epstein-Barr Virus (EBV) Followed by EBV-Positive T-Cell Lymphoma Blood, March 15, 1998; 91(6): 2085 - 2091. [Abstract] [Full Text] [PDF]

				J. V Ongkosuwito, A. Van der Lelij, M. Bruinenberg, M. W.-v. Doorn, E. J C Feron, C. B Hoyng, R. J W de Keizer, A.-M. Klok, and A. Kijlstra Increased presence of Epstein-Barr virus DNA in ocular fluid samples from HIV negative immunocompromised patients with uveitis Br. J. Ophthalmol., March 1, 1998; 82(3): 245 - 251. [Abstract] [Full Text]

				H. Nakagawa, T. Inomoto, and A. K. Rustgi A CACCC Box-like cis-Regulatory Element of the Epstein-Barr Virus ED-L2 Promoter Interacts with a Novel Transcriptional Factor in Tissue-specific Squamous Epithelia J. Biol. Chem., June 27, 1997; 272(26): 16688 - 16699. [Abstract] [Full Text] [PDF]

				S. J. Thaler and C. C. Compton Case 3-1997- A 39-Year-Old Man with Diarrhea and Abdominal Pain after Chemotherapy for Acute Leukemia N. Engl. J. Med., January 23, 1997; 336(4): 277 - 284. [Full Text] [PDF]

				R. Norville, D. Nance, and S. Cheshire Virus-Specific Cytotoxic T Lymphocytes as Prophylaxis for Epstein-Barr Virus Lymphoproliferative Disease in Pediatric Bone Marrow Transplant Recipients Journal of Pediatric Oncology Nursing, January 1, 1997; 14(4): 194 - 201. [Abstract] [PDF]

				G. Remuzzi and E. Gotti The Girl with the Curl N. Engl. J. Med., October 5, 1995; 333(14): 928 - 931. [Full Text] [PDF]