Figure 3. Mean symptom bothersomeness scale scores at baseline, 6, 12, and 26 weeks by treatment group. Classes ended at week 12. The x-axis signifies week after starting treatment. Higher scores signify greater symptom bothersomeness. The P values for the omnibus F tests of any differences in mean symptom bothersomeness scores among the 3 treatment groups (derived from a linear regression model fitted to all follow-up time points, adjusting for baseline symptom bothersomeness score by using generalized estimating equations) are 0.019 at 6 weeks, 0.135 at 12 weeks, and 0.001 at 26 weeks.