Figure 5. A 23-year-old unvaccinated woman with variola vera. The patient at day 4 (top), day 6 (middle), and day 11 (bottom) after the onset of illness. There appear to be purpuric lesions on days 6 and 11. A diagnosis of a hemorrhagic form of smallpox had been considered by staff shortly after admission. The patient died on day 12. (From clinical records of the Southampton Street smallpox hospital, Francis A. Countway Library of Medicine, Boston Medical Library, Boston.).