Figure 4. An unidentified nurse cleaning the eyes of a delirious 45-year-old man with variola vera (date of onset uncertain). The patient had a history of successful vaccination in infancy. On discharge 1 month later, he was described as "well": "weak on legs but is apparently mentally sound ... has one discharging boil on legs." (From clinical records of the Southampton Street smallpox hospital, Francis A. Countway Library of Medicine, Boston Medical Library, Boston.).