Figure 3. Day 8 of variola vera in a 3.5-year-old girl with an unidentified nurse at the Southampton Street smallpox hospital. The patient had been unsuccessfully vaccinated 3 months before admission. Pustules appear in the same stage (monomorphic)—a characteristic feature of smallpox. She was discharged "well" 1 month later, although facial pitting was noted. (From clinical records of the Southampton Street smallpox hospital, Francis A. Countway Library of Medicine, Boston Medical Library, Boston.).