Appendix (Figure 1). Analytical framework. KQ = key question. KQ 1: Do chemopreventive agents reduce mortality from breast cancer? KQ 2: Do chemopreventive agents reduce the incidence of breast cancer? KQ 3: Do chemopreventive agents have other beneficial effects? KQ 4: Do chemopreventive agents increase the risk for adverse effects? KQ 5: What are the costs associated with chemoprevention of breast cancer?